铁钼多金属氧酸盐及其组分混合物的毒性作用比较

I. Gette, Aleksandr Aleksandrovich Ostroushko, I. Danilova, M. Tonkushina
{"title":"铁钼多金属氧酸盐及其组分混合物的毒性作用比较","authors":"I. Gette, Aleksandr Aleksandrovich Ostroushko, I. Danilova, M. Tonkushina","doi":"10.36946/0869-7922-2021-29-6-54-59","DOIUrl":null,"url":null,"abstract":"Introduction. The physicochemical properties and the impact on living organisms of nanoparticles and components that make up nanoparticles may differ radically, however, insufficient attention is paid to a comparative study of the toxicity of nanoparticles and constituents of nanoparticles. Material and methods. Biochemical and hematological parameters in the blood of 50 male Wistar rats were determined after a single, seven-fold and thirty-fold intramuscular injection of an aqueous solution of iron-molybdenum nanocluster polyoxometalates (POM) and a mixture of the POM components at a dose of 1.5 mg/kg. A solution of a POM components’ mixture was obtained by the destruction of POM with an increase in pH, followed by neutralization, since POM are unstable in an alkaline medium. Results. The introduction of POM did not cause deviations from the norm in the activity of AST, ALT, total alkaline phosphatase and its bone isoenzyme, α-amylase, protein content, urea and creatinine, which indicates the absence of cytolytic syndrome, including in the liver and myocardium, no damage to the acinar part of pancreas, changes in bone tissue, preservation of the protein-synthetic function of the liver and the filtering ability of the kidneys. The introduction of a solution of POM components (molybdenum, iron) was accompanied by an increase in the activity of AST, alkaline phosphatase, the AST / ALT ratio after 7 injections and an increase in the last two parameters after 30 injections. The impact of POM is characterized by an increase in the content of hemoglobin and erythrocytes in the blood and less pronounced leukopenia, in contrast to the mixture of POM components. Conclusion. A less pronounced deviation from the norm of biochemical parameters and a lower degree of leukopenia make it possible to assess the effect of POM nanoparticles as less toxic than the action of POM components not organized into nanoparticles.","PeriodicalId":23128,"journal":{"name":"Toxicological Review","volume":"19 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of toxic effects of iron-molybdenum polyoxometalates and mixture of their components\",\"authors\":\"I. Gette, Aleksandr Aleksandrovich Ostroushko, I. Danilova, M. Tonkushina\",\"doi\":\"10.36946/0869-7922-2021-29-6-54-59\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction. The physicochemical properties and the impact on living organisms of nanoparticles and components that make up nanoparticles may differ radically, however, insufficient attention is paid to a comparative study of the toxicity of nanoparticles and constituents of nanoparticles. Material and methods. Biochemical and hematological parameters in the blood of 50 male Wistar rats were determined after a single, seven-fold and thirty-fold intramuscular injection of an aqueous solution of iron-molybdenum nanocluster polyoxometalates (POM) and a mixture of the POM components at a dose of 1.5 mg/kg. A solution of a POM components’ mixture was obtained by the destruction of POM with an increase in pH, followed by neutralization, since POM are unstable in an alkaline medium. Results. The introduction of POM did not cause deviations from the norm in the activity of AST, ALT, total alkaline phosphatase and its bone isoenzyme, α-amylase, protein content, urea and creatinine, which indicates the absence of cytolytic syndrome, including in the liver and myocardium, no damage to the acinar part of pancreas, changes in bone tissue, preservation of the protein-synthetic function of the liver and the filtering ability of the kidneys. The introduction of a solution of POM components (molybdenum, iron) was accompanied by an increase in the activity of AST, alkaline phosphatase, the AST / ALT ratio after 7 injections and an increase in the last two parameters after 30 injections. The impact of POM is characterized by an increase in the content of hemoglobin and erythrocytes in the blood and less pronounced leukopenia, in contrast to the mixture of POM components. Conclusion. A less pronounced deviation from the norm of biochemical parameters and a lower degree of leukopenia make it possible to assess the effect of POM nanoparticles as less toxic than the action of POM components not organized into nanoparticles.\",\"PeriodicalId\":23128,\"journal\":{\"name\":\"Toxicological Review\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicological Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36946/0869-7922-2021-29-6-54-59\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicological Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36946/0869-7922-2021-29-6-54-59","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

介绍。纳米粒子及其组成成分的物理化学性质和对生物体的影响可能有根本的不同,然而,对纳米粒子及其组成成分的毒性的比较研究重视不够。材料和方法。研究了50只雄性Wistar大鼠单次、7次和30次肌肉注射铁钼纳米团块多金属氧酸盐(POM)水溶液和POM组分的混合物(剂量为1.5 mg/kg)后血液的生化和血液学参数。由于POM在碱性介质中不稳定,因此通过pH值的增加来破坏POM,然后进行中和,得到POM组分混合物的溶液。结果。POM的引入未引起AST、ALT、总碱性磷酸酶及其骨同功酶、α-淀粉酶、蛋白质含量、尿素和肌酐的活性偏离正常值,表明肝脏和心肌不存在溶细胞综合征,胰腺腺泡部分未受到损害,骨组织发生改变,肝脏蛋白质合成功能和肾脏过滤能力得以保留。添加POM组分(钼、铁)溶液后,7次注射后AST、碱性磷酸酶活性和AST / ALT比值升高,30次注射后后2项参数升高。与混合POM成分相比,POM的影响特点是血液中血红蛋白和红细胞含量增加,白细胞减少不太明显。结论。与生化参数标准偏差较小,白细胞减少程度较低,因此可以评估POM纳米颗粒的作用比未组织成纳米颗粒的POM成分的作用毒性更小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Comparison of toxic effects of iron-molybdenum polyoxometalates and mixture of their components
Introduction. The physicochemical properties and the impact on living organisms of nanoparticles and components that make up nanoparticles may differ radically, however, insufficient attention is paid to a comparative study of the toxicity of nanoparticles and constituents of nanoparticles. Material and methods. Biochemical and hematological parameters in the blood of 50 male Wistar rats were determined after a single, seven-fold and thirty-fold intramuscular injection of an aqueous solution of iron-molybdenum nanocluster polyoxometalates (POM) and a mixture of the POM components at a dose of 1.5 mg/kg. A solution of a POM components’ mixture was obtained by the destruction of POM with an increase in pH, followed by neutralization, since POM are unstable in an alkaline medium. Results. The introduction of POM did not cause deviations from the norm in the activity of AST, ALT, total alkaline phosphatase and its bone isoenzyme, α-amylase, protein content, urea and creatinine, which indicates the absence of cytolytic syndrome, including in the liver and myocardium, no damage to the acinar part of pancreas, changes in bone tissue, preservation of the protein-synthetic function of the liver and the filtering ability of the kidneys. The introduction of a solution of POM components (molybdenum, iron) was accompanied by an increase in the activity of AST, alkaline phosphatase, the AST / ALT ratio after 7 injections and an increase in the last two parameters after 30 injections. The impact of POM is characterized by an increase in the content of hemoglobin and erythrocytes in the blood and less pronounced leukopenia, in contrast to the mixture of POM components. Conclusion. A less pronounced deviation from the norm of biochemical parameters and a lower degree of leukopenia make it possible to assess the effect of POM nanoparticles as less toxic than the action of POM components not organized into nanoparticles.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Toxic pollution: current aspects of plastic waste management, optimal solutions without prohibitive measures usage Mass hydrogen sulfide poisoning and the role of forensic medical examination in proving Development and validation of a method for the quantitative determination of metoprolol succinate in the air of the working area by high-performance liquid chromatography using mass spectra Effect of subchronic use of unsymmetrical dimethylhydrazine on contractile activity of isolated lymphatic vessels Assessment and classification of the danger of endocrine disruptors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1