{"title":"合成N,N ' -双(苯氧乙酰基)肼的新方法","authors":"Çağla Begüm Apaydın, Z. Cesur","doi":"10.26650/ISTANBULJPHARM.2019.19002","DOIUrl":null,"url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19002 This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives. Cite this article as: Apaydin CB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines\",\"authors\":\"Çağla Begüm Apaydın, Z. Cesur\",\"doi\":\"10.26650/ISTANBULJPHARM.2019.19002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"DOI : 10.26650/IstanbulJPharm.2019.19002 This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives. Cite this article as: Apaydin CB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.\",\"PeriodicalId\":14484,\"journal\":{\"name\":\"İstanbul Journal of Pharmacy\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"İstanbul Journal of Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26650/ISTANBULJPHARM.2019.19002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"İstanbul Journal of Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26650/ISTANBULJPHARM.2019.19002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines
DOI : 10.26650/IstanbulJPharm.2019.19002 This report is about an unexpected formation of N,N’-bis(substituted phenoxyacetyl) hydrazine derivatives. The reaction between N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide with sulfanyl acids to obtain 4-thiazolidinones s, gave an unexpected product, N,N’-bis(phenoxyacetyl)hydrazine, with high purity instead of the expected cyclocondensation product. When repeating the reaction with p-toluenesulfonic acid under the same conditions, the reaction resulted in the same compound. This indicates that two molecules of N’-(4-ethylcyclohexylidene)phenoxyacetohydrazide were involved in the reaction. The reaction can be applied as a different and new procedure for the synthesis of several N,N’-bis(substituted phenoxyacetyl)hydrazine derivatives. Cite this article as: Apaydin CB, Cesur Z (2019). A new approach for the synthesis of N,N’-bis(phenoxyacetyl)hydrazines. Istanbul J Pharm 49 (2): 61-63.