通过高分辨率四维HPCH实验,利用数据库挖掘和支持向量回归对牙龈癌细胞的DNA/RNA进行诊断,顺序分配牙龈癌细胞中13c标记的DNA/RNA

A. Heidari, R. Gobato
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引用次数: 10

摘要

本研究通过高分辨率四维HPCH实验,利用数据库挖掘和支持向量回归技术,对龈癌细胞中13c标记的DNA/RNA进行序列定位,研究龈癌细胞DNA/RNA诊断方法。在活检样本中诊断牙龈癌依赖于形态学分析,使用组织病理学家或细胞学家的专业知识,他们在观察这些标本方面有多年的经验。通过数据库挖掘和支持向量回归,通过高分辨率4D HPCH实验,对牙龈癌细胞中13c标记的DNA/RNA进行顺序分配,其中基因谱可以使用微阵列平台进行可视化,从而使牙龈癌细胞的DNA/RNA诊断可视化,从而增强了这一点。特征性易位可以用荧光原位杂交(FISH)检测,特别是在血液病理学中。利用光学方法研究牙龈癌细胞正在迅速发展,通过高分辨率4D HPCH实验,利用数据库挖掘和支持向量回归从DNA/RNA诊断牙龈癌细胞,为牙龈癌细胞中13c标记的DNA/RNA序列分配提供了一种新的模式,具有广阔的应用前景。
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Diagnosis of gum cancer cells from DNA/RNA using database mining and support vector regression through high resolution 4D HPCH experiment for sequential assignment of 13C–labeled DNAs/RNAs in gum cancer cells
In the current research, diagnosis of gum cancer cells from DNA/RNA using database mining and support vector regression through high resolution 4D HPCH experiment for sequential assignment of 13C–labeled DNAs/RNAs in gum cancer cells are investigated. Diagnosis of gum cancer in biopsy samples relies on morphological analysis using the expertise of histopathologists or cytologists who have many years’ experience in viewing these specimens. This is augmented by techniques which allow gum cancer specific markers to be visualized using diagnosis of gum cancer cells from DNA/RNA using database mining and support vector regression through high resolution 4D HPCH experiment for sequential assignment of 13C–labeled DNAs/RNAs in gum cancer cells, where gene profiles can be visualized using microarray platforms. Characteristic translocations can be detected using fluorescent in situ hybridization (FISH), particularly in haematopathology. The use of optical methods to interrogate gum cancer cells is developing rapidly and diagnosis of gum cancer cells from DNA/RNA using database mining and support vector regression through high resolution 4D HPCH experiment for sequential assignment of 13C–labeled DNAs/RNAs in gum cancer cells provides a new modality, which shows much promise.
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