{"title":"呼气气溶胶pH值是空气传播甲型流感病毒持续存在的驱动因素。","authors":"Aline Schaub","doi":"10.2533/chimia.2023.196","DOIUrl":null,"url":null,"abstract":"<p><p>To mitigate the spread of a viral disease, it is crucial to understand the factors that influence airborne virus transmission. However, the micro-environment to which the virus is exposed in expiratory aerosol particles is highly complex. The relative humidity, the aerosol particle size and composition, and the air composition affect virus infectivity by modulating the salt and organic concentrations within the particle, as well as the phase state. A parameter that has been overlooked is the aerosol pH. Several viruses are sensitive to acidic pH; for example, the inactivation of influenza A virus becomes very fast at pH 5.5 and below, a threshold that is quickly reached in an expiratory aerosol particle exhaled in a typical indoor environment. Therefore, aerosol acidity plays a significant role in controlling the persistence of airborne, acid-sensitive viruses such as influenza virus, and aerosol pH control could be applied to limit the risk of airborne virus transmission.</p>","PeriodicalId":13658,"journal":{"name":"Integral Equations and Operator Theory","volume":"61 1","pages":"196-200"},"PeriodicalIF":0.8000,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expiratory Aerosol pH is a Driver of the Persistence of Airborne Influenza A Virus.\",\"authors\":\"Aline Schaub\",\"doi\":\"10.2533/chimia.2023.196\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>To mitigate the spread of a viral disease, it is crucial to understand the factors that influence airborne virus transmission. However, the micro-environment to which the virus is exposed in expiratory aerosol particles is highly complex. The relative humidity, the aerosol particle size and composition, and the air composition affect virus infectivity by modulating the salt and organic concentrations within the particle, as well as the phase state. A parameter that has been overlooked is the aerosol pH. Several viruses are sensitive to acidic pH; for example, the inactivation of influenza A virus becomes very fast at pH 5.5 and below, a threshold that is quickly reached in an expiratory aerosol particle exhaled in a typical indoor environment. Therefore, aerosol acidity plays a significant role in controlling the persistence of airborne, acid-sensitive viruses such as influenza virus, and aerosol pH control could be applied to limit the risk of airborne virus transmission.</p>\",\"PeriodicalId\":13658,\"journal\":{\"name\":\"Integral Equations and Operator Theory\",\"volume\":\"61 1\",\"pages\":\"196-200\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-04-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Integral Equations and Operator Theory\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2533/chimia.2023.196\",\"RegionNum\":3,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATHEMATICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integral Equations and Operator Theory","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2533/chimia.2023.196","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATHEMATICS","Score":null,"Total":0}
Expiratory Aerosol pH is a Driver of the Persistence of Airborne Influenza A Virus.
To mitigate the spread of a viral disease, it is crucial to understand the factors that influence airborne virus transmission. However, the micro-environment to which the virus is exposed in expiratory aerosol particles is highly complex. The relative humidity, the aerosol particle size and composition, and the air composition affect virus infectivity by modulating the salt and organic concentrations within the particle, as well as the phase state. A parameter that has been overlooked is the aerosol pH. Several viruses are sensitive to acidic pH; for example, the inactivation of influenza A virus becomes very fast at pH 5.5 and below, a threshold that is quickly reached in an expiratory aerosol particle exhaled in a typical indoor environment. Therefore, aerosol acidity plays a significant role in controlling the persistence of airborne, acid-sensitive viruses such as influenza virus, and aerosol pH control could be applied to limit the risk of airborne virus transmission.
期刊介绍：
Integral Equations and Operator Theory (IEOT) is devoted to the publication of current research in integral equations, operator theory and related topics with emphasis on the linear aspects of the theory. The journal reports on the full scope of current developments from abstract theory to numerical methods and applications to analysis, physics, mechanics, engineering and others. The journal consists of two sections: a main section consisting of refereed papers and a second consisting of short announcements of important results, open problems, information, etc.
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