黄芪的二萜类和酚类含量。边沁具有抗氧化和抗胆碱酯酶活性

S. Carikci, A. Goren, T. Kilic
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引用次数: 5

摘要

摘要本研究的目的是测定空心黄芪挥发油、二萜和酚类物质的含量及其生物活性。发现叶绿醇是精油的主要成分。用液相色谱-串联质谱法(LC-MS/MS)测定了7种已知的桃金酮类二萜类化合物:苷醇(140 mg, 0.16%, w/w)、7-乙酰氧基桃金醇(15 mg, 0.02%, w/w)、戊三醇(5 mg, 0.03%, w/w)、7-表二甘醇(3 mg, 0.02%, w/w)、烯-7α-乙酰氧基-18-羟基桃金醇-16-烯(5 mg, 0.01%, w/w)和线性醇[液相色谱-串联质谱法]。此外,从S. hololeuca的丙酮提取物中分离到香兰素(21 mg, 0.10%, w/w),此前未从任何一种Sideritis中分离到香兰素。采用LC-MS/MS对正己烷、二氯甲烷、丙酮、甲醇提取液、浸膏和煎剂中部分酚类化合物的含量进行了测定。对其抗氧化能力和抑制乙酰胆碱酯酶、丁基胆碱酯酶的作用进行了评价。甲醇提取液、灌液和煎液对丁胆碱酯酶的抑制作用中等。其中,以种属煎剂的抑制作用最强。测定输注Cu2+还原力为1.435 mmol TR g−1。
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Diterpenoid and phenolic contents of Sideritis hololeuca Boiss & Heldr. Apud Bentham with antioxidant and anticholinesterase activity
Abstract The objective of this study is to determine essential oil, diterpenoid and phenolic contents of Sideritis hololeuca along with their biological activities. Phytol was found to be the main component of the essential oil. Seven known kaurane diterpenoids, siderol (140 mg, 0.16%, w/w), 7-acetoxy sideroxol (15 mg, 0.02%, w/w), eubol (6 mg, 0.01%, w/w), eubotriol (5 mg, 0.03%, w/w), 7-epicandicandiol (3 mg, 0.02%, w/w), ent-7α-acetoxy-18-hydroxykaur-16-ene (5 mg, 0.01%, w/w) and linearol [by liquid chromatography-tandem mass spectrometry (LC-MS/MS)] were determined from the species. Moreover, vanillin (21 mg, 0.10%, w/w), which was not isolated from any Sideritis species earlier, was isolated from an acetone extract of S. hololeuca. Quantitative amounts of some phenolic compounds in n-hexane, dichloromethane, acetone, methanol extracts and infusion and decoction of the plants were also investigated by LC-MS/MS. Antioxidant capacity and acetylcholinesterase, butyrylcholinesterase inhibition effects of the species were evaluated. The extracts of methanol and infusion and decoction of species showed moderate butyrylcholinesterase inhibition activity. The highest inhibition was observed from the decoction of species. The Cu2+ reducing power of infusion was determined as 1.435 mmol TR g−1.
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