Langerhans cells containing calcifying epithelial odontogenic tumour: Report of two cases and review of the literature

Two cases (intraosseous and extraosseous lesion, respectively) of rare calcifying epithelial odontogenic tumors with Langerhans cells were reported. The tumors were examined by HE, PAS and Congo red staining, ultrastructural and immunohistochemical observation for Langerhans cells labeling antibodies (CD1a, CD68 , HLA-DR and S-100). The tumours chiefly consisted of small nests (cords) of epithelial cells, homogenous material and scarce calcification and few epithelial cells showed positive for these specific antibodies. Ultrastructural studies found Langerhans cells with Birbeck’s granules among tumor cells. Ultrastructural analysis and positive immunoreactivities suggested the two cases be Langerhans cells containing calcifying epithelial odontogenic tumors.