利用纳米技术进行早期癌症检测和治疗

Adem Beriso
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引用次数: 5

摘要

到目前为止,癌症的检测和治疗方法大多无效,主要有以下两个原因。首先,患者在生病的时候去健康中心,很可能是在很长一段时间后,癌细胞在他们的体内产生,或者他们自己的方法是非特异性的筛查方法,这往往导致癌症的晚期检测到有效的治疗,其中一些方法可能会破坏正常细胞,甚至可能导致癌症。其次,目前的癌症治疗方法是非选择性和毒性的,会杀死异常和正常细胞,导致严重的副作用。纳米技术在卫生部门的应用,特别是其在早期阶段发现癌症和在减少毒性的同时进行全面治疗的能力,有望对一般的卫生保健,特别是癌症产生深远的影响。这项新技术已经显示出在早期阶段检测癌症的潜力,并通过使用纳米颗粒的独特特性,增加肿瘤细胞治疗的特异性,同时使健康细胞不受损害。本文综述了量子点、磁性纳米粒子、金纳米粒子、聚合物胶束、脂质体、树状大分子和多孔硅纳米粒子等纳米粒子在癌症早期检测和治疗中的应用。
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Early Cancer Detection and Treatment with Nanotechnology
Until now cancer detection and treatment methods are mostly ineffective due to the following two main reasons. Firstly, patients go to health center when they feel ill, most probably after cancer cells created in their body some long time later and/or the methods by themselves are non-specific screening methods, which often resulted in late cancer detection for effective treatment and some of these methods may be destructive to normal cells or even can cause cancer. Secondly, current cancer treatment methods are non-selection and toxic those kill both abnormal and normal cells leading to serious side effects. The use of nanotechnology to health sector, particularly its ability to detect cancer in its early stage and for complete treatment along with reducing toxicity, promises to have a deep impact on healthcare in general and on cancer in particular. This new technology has already shown the potential to detect cancer in its early stage and to increase the specificity of treatment of tumor cells while leaving healthy cells undamaged through the use of the unique properties of nanoparticles. This review discusses the use of nanoparticles such as quantum dots, magnetic nanoparticles, gold nanoparticles, polymeric micelles, liposomes, dendrimers and porous silicon nanoparticles for the early detection and treatment of cancer.
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