Molecular Charge Transfer Complexes of Norfloxacin with Nitrobenzenes

Abstract Charge Transfer molecular complexes of Norfloxacin-[1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl) 3-quinolone carboxylic acid] with m-dinitrobenzene, picric acid, 3,5-dinitrobenzoic acid and 3,5-dinitrosalicylic acid have been synthesized and characterized by elemental analysis as well as different spectroscopic techniques. Spectral characteristics and stability of the complexes are investigated and discussed in terms of donor molecular structure, π-acceptor electron affinity, and solvent polarity. It is deduced that the complexes are mainly of the n–π* and π–π* types. Ionization potential of the donor was estimated from the CT transition energies of their complexes. The potentiality of the electron acceptors as new chromophoric reagents for the spectrophotometric determination of Norfloxacin was studied by extensive investigation of optimum conditions favouring the formation of the colored complexes.