离子和非离子表面活性剂胶束溶液提高舒林酸的水溶性

{"title":"离子和非离子表面活性剂胶束溶液提高舒林酸的水溶性","authors":"","doi":"10.47262/bl/8.2.20220226","DOIUrl":null,"url":null,"abstract":"In the science of pharmacology, solubility plays a crucial role in the efficacy and bioavailability of the drug. Utilizing solubility features to improve the bioavailability and pharmacological effect of diverse weakly soluble substances, is an arduous task for pharmaceutical experts and researchers. Particle size, surface area, physicochemical qualities, physical forms of drugs, solvents and surfactant usage are parameters that influence solubility. The objective of the current study was to enhance the solubility of the non-steroidal anti-inflammatory drug (NSAID): Sulindac. The micellar solutions method was employed with different surfactants to increase the efficiency. Both nonionic (Tween 20, 40, 60 and 80 with Brij 30, 35 and 56) and ionic (SDS, SDBS, CTAB, TTAB and DTAB) surfactants were investigated for their effect on drug solubility in aqueous solution. Various parameters of surfactant solutions such as aggregation number, micelle-water partition coefficient (KM), molar solubilization ratio (MSR), Gibbs energy of solubilization (∆Gº s), size of micelle and binding constant of the drug micelles were measured. Finding reveals that the use of mentioned surfactant is an excellent approach to enhancing the solubility of sulindac. Furthermore, the present work provides an understanding of the relation of aqueous solubility with aggregation number and structure of surfactants used.","PeriodicalId":9154,"journal":{"name":"Biomedical Letters","volume":"36 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Enhancement in aqueous solubility of sulindac medicine by using the micellar solution of ionic and non-ionic surfactants\",\"authors\":\"\",\"doi\":\"10.47262/bl/8.2.20220226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the science of pharmacology, solubility plays a crucial role in the efficacy and bioavailability of the drug. Utilizing solubility features to improve the bioavailability and pharmacological effect of diverse weakly soluble substances, is an arduous task for pharmaceutical experts and researchers. Particle size, surface area, physicochemical qualities, physical forms of drugs, solvents and surfactant usage are parameters that influence solubility. The objective of the current study was to enhance the solubility of the non-steroidal anti-inflammatory drug (NSAID): Sulindac. The micellar solutions method was employed with different surfactants to increase the efficiency. Both nonionic (Tween 20, 40, 60 and 80 with Brij 30, 35 and 56) and ionic (SDS, SDBS, CTAB, TTAB and DTAB) surfactants were investigated for their effect on drug solubility in aqueous solution. Various parameters of surfactant solutions such as aggregation number, micelle-water partition coefficient (KM), molar solubilization ratio (MSR), Gibbs energy of solubilization (∆Gº s), size of micelle and binding constant of the drug micelles were measured. Finding reveals that the use of mentioned surfactant is an excellent approach to enhancing the solubility of sulindac. Furthermore, the present work provides an understanding of the relation of aqueous solubility with aggregation number and structure of surfactants used.\",\"PeriodicalId\":9154,\"journal\":{\"name\":\"Biomedical Letters\",\"volume\":\"36 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47262/bl/8.2.20220226\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47262/bl/8.2.20220226","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

在药理学中,溶解度对药物的有效性和生物利用度起着至关重要的作用。利用溶解度特性来提高各种弱溶性物质的生物利用度和药理作用,是药学专家和研究人员面临的一项艰巨任务。粒径、表面积、理化性质、药物的物理形态、溶剂和表面活性剂的使用是影响溶解度的参数。本研究的目的是提高非甾体抗炎药(NSAID)的溶解度:舒林酸。采用不同表面活性剂的胶束溶液法提高了效率。研究了非离子型表面活性剂(Tween 20、40、60和80,Brij为30、35和56)和离子型表面活性剂(SDS、SDBS、CTAB、TTAB和DTAB)对药物在水溶液中溶解度的影响。测定了表面活性剂溶液的聚集数、胶束-水分配系数(KM)、摩尔增溶比(MSR)、吉布斯增溶能(∆Gºs)、胶束大小和药物胶束结合常数等参数。结果表明,使用上述表面活性剂是提高舒林酸溶解度的一种很好的方法。此外,本工作提供了对水溶解度与表面活性剂的聚集数和结构的关系的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Enhancement in aqueous solubility of sulindac medicine by using the micellar solution of ionic and non-ionic surfactants
In the science of pharmacology, solubility plays a crucial role in the efficacy and bioavailability of the drug. Utilizing solubility features to improve the bioavailability and pharmacological effect of diverse weakly soluble substances, is an arduous task for pharmaceutical experts and researchers. Particle size, surface area, physicochemical qualities, physical forms of drugs, solvents and surfactant usage are parameters that influence solubility. The objective of the current study was to enhance the solubility of the non-steroidal anti-inflammatory drug (NSAID): Sulindac. The micellar solutions method was employed with different surfactants to increase the efficiency. Both nonionic (Tween 20, 40, 60 and 80 with Brij 30, 35 and 56) and ionic (SDS, SDBS, CTAB, TTAB and DTAB) surfactants were investigated for their effect on drug solubility in aqueous solution. Various parameters of surfactant solutions such as aggregation number, micelle-water partition coefficient (KM), molar solubilization ratio (MSR), Gibbs energy of solubilization (∆Gº s), size of micelle and binding constant of the drug micelles were measured. Finding reveals that the use of mentioned surfactant is an excellent approach to enhancing the solubility of sulindac. Furthermore, the present work provides an understanding of the relation of aqueous solubility with aggregation number and structure of surfactants used.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Incidence and risk factors associated with peptic ulcer in different cities of Punjab, Pakistan Human monkeypox virus: A review on the globally emerging virus Recent progress in the application of biodegradable metal implants Recent progress in the application of biodegradable metal implants Bioimpedance spectroscopy characterization of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) peripheral blood mononuclear cells
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1