体育活动后慢性精神分裂症患者的蛋白质组学和代谢谱:初步研究

IF 5.2 3区 医学 Q1 PSYCHIATRY Revista de psiquiatria y salud mental Pub Date : 2021-07-01 DOI:10.1016/j.rpsm.2020.11.001
María del Carmen Vallejo-Curto , Daniela Rodrigues-Amorim , Laura Jardón-Golmar , María Blanco-Formoso , Tania Rivera-Baltanás , Cynthia Rodriguez-Jamardo , Patricia Fernández-Palleiro , María Álvarez-Ariza , Marta López-García , Alejandro García-Caballero , Elena de las Heras , José Manuel Olivares , Carlos Spuch
{"title":"体育活动后慢性精神分裂症患者的蛋白质组学和代谢谱:初步研究","authors":"María del Carmen Vallejo-Curto ,&nbsp;Daniela Rodrigues-Amorim ,&nbsp;Laura Jardón-Golmar ,&nbsp;María Blanco-Formoso ,&nbsp;Tania Rivera-Baltanás ,&nbsp;Cynthia Rodriguez-Jamardo ,&nbsp;Patricia Fernández-Palleiro ,&nbsp;María Álvarez-Ariza ,&nbsp;Marta López-García ,&nbsp;Alejandro García-Caballero ,&nbsp;Elena de las Heras ,&nbsp;José Manuel Olivares ,&nbsp;Carlos Spuch","doi":"10.1016/j.rpsm.2020.11.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Schizophrenia is a chronic illness often accompanied by metabolic disorders, diabetes, obesity and cardiovascular problems often associated with unhealthy lifestyles, as well as neuroendocrine problems caused by the disease itself. Lifestyle changes, such as regular physical exercise, have a positive effect on metabolic disorders and mental health, although the molecular changes that occur in this type of patient and how they explain the changes in their response are unknown. This study wants to analyze in a novel way the proteins and molecular pathways involved in critical plasmatic proteins in plasma to reveal the pathways involved in the implementation of physical exercise and the changes that occur among patients who participate in such programs with those who leave.</p></div><div><h3>Methods</h3><p>Twenty-one patients with chronic schizophrenia underwent a daily, 6-month aerobic training program. We divided them into a group that completed the program (12 patients) and a second group that left the training program (9 patients). The biochemical and clinical data of each patient were analyzed and the proteomic profile of the plasma was studied using ESI-LC-MS/MS.</p></div><div><h3>Results</h3><p>Proteomic analysis recognizes 21.165 proteins and peptides in each patient, of which we identified 1,812 proteins that varied between both groups linked to the metabolic and biological regulation pathways. After clinical analysis of each patient we found significant differences in weight, BMI, abdominal perimeter, diastolic blood pressure, and HDL cholesterol levels. The main change that vertebrates both groups is the Self-Assessment Anhedonia Scale, where we detected higher levels in the dropout group (no physical activity) compared to the active group.</p></div><div><h3>Conclusion</h3><p>The benefits of physical exercise are clear in chronic patients with schizophrenia, as it substantially improves their BMI, as well as their clinical and biochemical parameters. However, our study reveals the biological and molecular pathways that affect physical exercise in schizophrenia, such as important metabolic proteins such as ApoE and ApoC, proteins involved in neuronal regulation such as tenascin and neurotrophins, neuroinflammatory regulatory pathways such as lipocalin-2 and protein 14-3-3, as well as cytoskeleton proteins of cells such as spectrins and annexines. Understanding these molecular mechanisms opens the door to future therapies in the chronicity of schizophrenia.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":5.2000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989120301245/pdfft?md5=302453eb95cf6240092a6d5d86e331f6&pid=1-s2.0-S1888989120301245-main.pdf","citationCount":"2","resultStr":"{\"title\":\"Perfil proteómico y metabólico de pacientes crónicos con esquizofrenia tras un programa de actividad física: estudio piloto\",\"authors\":\"María del Carmen Vallejo-Curto ,&nbsp;Daniela Rodrigues-Amorim ,&nbsp;Laura Jardón-Golmar ,&nbsp;María Blanco-Formoso ,&nbsp;Tania Rivera-Baltanás ,&nbsp;Cynthia Rodriguez-Jamardo ,&nbsp;Patricia Fernández-Palleiro ,&nbsp;María Álvarez-Ariza ,&nbsp;Marta López-García ,&nbsp;Alejandro García-Caballero ,&nbsp;Elena de las Heras ,&nbsp;José Manuel Olivares ,&nbsp;Carlos Spuch\",\"doi\":\"10.1016/j.rpsm.2020.11.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Schizophrenia is a chronic illness often accompanied by metabolic disorders, diabetes, obesity and cardiovascular problems often associated with unhealthy lifestyles, as well as neuroendocrine problems caused by the disease itself. Lifestyle changes, such as regular physical exercise, have a positive effect on metabolic disorders and mental health, although the molecular changes that occur in this type of patient and how they explain the changes in their response are unknown. This study wants to analyze in a novel way the proteins and molecular pathways involved in critical plasmatic proteins in plasma to reveal the pathways involved in the implementation of physical exercise and the changes that occur among patients who participate in such programs with those who leave.</p></div><div><h3>Methods</h3><p>Twenty-one patients with chronic schizophrenia underwent a daily, 6-month aerobic training program. We divided them into a group that completed the program (12 patients) and a second group that left the training program (9 patients). The biochemical and clinical data of each patient were analyzed and the proteomic profile of the plasma was studied using ESI-LC-MS/MS.</p></div><div><h3>Results</h3><p>Proteomic analysis recognizes 21.165 proteins and peptides in each patient, of which we identified 1,812 proteins that varied between both groups linked to the metabolic and biological regulation pathways. After clinical analysis of each patient we found significant differences in weight, BMI, abdominal perimeter, diastolic blood pressure, and HDL cholesterol levels. The main change that vertebrates both groups is the Self-Assessment Anhedonia Scale, where we detected higher levels in the dropout group (no physical activity) compared to the active group.</p></div><div><h3>Conclusion</h3><p>The benefits of physical exercise are clear in chronic patients with schizophrenia, as it substantially improves their BMI, as well as their clinical and biochemical parameters. However, our study reveals the biological and molecular pathways that affect physical exercise in schizophrenia, such as important metabolic proteins such as ApoE and ApoC, proteins involved in neuronal regulation such as tenascin and neurotrophins, neuroinflammatory regulatory pathways such as lipocalin-2 and protein 14-3-3, as well as cytoskeleton proteins of cells such as spectrins and annexines. Understanding these molecular mechanisms opens the door to future therapies in the chronicity of schizophrenia.</p></div>\",\"PeriodicalId\":21391,\"journal\":{\"name\":\"Revista de psiquiatria y salud mental\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1888989120301245/pdfft?md5=302453eb95cf6240092a6d5d86e331f6&pid=1-s2.0-S1888989120301245-main.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista de psiquiatria y salud mental\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1888989120301245\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista de psiquiatria y salud mental","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1888989120301245","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 2

摘要

精神分裂症是一种慢性疾病,通常伴有代谢紊乱、糖尿病、肥胖和心血管问题,这些问题往往与不健康的生活方式有关,以及由疾病本身引起的神经内分泌问题。生活方式的改变,如定期体育锻炼,对代谢紊乱和精神健康有积极影响,尽管这类患者发生的分子变化以及它们如何解释其反应的变化尚不清楚。本研究希望以一种新颖的方式分析血浆中涉及关键血浆蛋白的蛋白质和分子途径,以揭示参与体育锻炼的途径,以及参与体育锻炼的患者与退出体育锻炼的患者之间发生的变化。方法21例慢性精神分裂症患者每天进行6个月的有氧训练。我们将他们分为两组,一组完成了训练(12名患者),另一组结束了训练(9名患者)。采用ESI-LC-MS/MS分析每位患者的生化和临床数据,并研究血浆蛋白质组学特征。结果蛋白质组学分析在每个患者中识别21.165个蛋白质和肽,其中我们确定了1,812个蛋白质在两组之间与代谢和生物调节途径相关。在对每位患者进行临床分析后,我们发现在体重、BMI、腹部周长、舒张压和高密度脂蛋白胆固醇水平上存在显著差异。两组脊椎动物的主要变化是自我评估缺乏症量表,我们在其中检测到退学组(没有体育锻炼)的水平高于积极锻炼组。结论体育锻炼对慢性精神分裂症患者的益处是明显的,因为它可以显著改善他们的BMI,以及他们的临床和生化参数。然而,我们的研究揭示了影响精神分裂症患者体育锻炼的生物学和分子途径,如重要的代谢蛋白如ApoE和ApoC,参与神经元调节的蛋白质如腱素和神经营养蛋白,神经炎症调节途径如脂钙素-2和14-3-3蛋白,以及细胞的细胞骨架蛋白如spectrins和annexine。了解这些分子机制为今后治疗慢性精神分裂症打开了大门。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Perfil proteómico y metabólico de pacientes crónicos con esquizofrenia tras un programa de actividad física: estudio piloto

Introduction

Schizophrenia is a chronic illness often accompanied by metabolic disorders, diabetes, obesity and cardiovascular problems often associated with unhealthy lifestyles, as well as neuroendocrine problems caused by the disease itself. Lifestyle changes, such as regular physical exercise, have a positive effect on metabolic disorders and mental health, although the molecular changes that occur in this type of patient and how they explain the changes in their response are unknown. This study wants to analyze in a novel way the proteins and molecular pathways involved in critical plasmatic proteins in plasma to reveal the pathways involved in the implementation of physical exercise and the changes that occur among patients who participate in such programs with those who leave.

Methods

Twenty-one patients with chronic schizophrenia underwent a daily, 6-month aerobic training program. We divided them into a group that completed the program (12 patients) and a second group that left the training program (9 patients). The biochemical and clinical data of each patient were analyzed and the proteomic profile of the plasma was studied using ESI-LC-MS/MS.

Results

Proteomic analysis recognizes 21.165 proteins and peptides in each patient, of which we identified 1,812 proteins that varied between both groups linked to the metabolic and biological regulation pathways. After clinical analysis of each patient we found significant differences in weight, BMI, abdominal perimeter, diastolic blood pressure, and HDL cholesterol levels. The main change that vertebrates both groups is the Self-Assessment Anhedonia Scale, where we detected higher levels in the dropout group (no physical activity) compared to the active group.

Conclusion

The benefits of physical exercise are clear in chronic patients with schizophrenia, as it substantially improves their BMI, as well as their clinical and biochemical parameters. However, our study reveals the biological and molecular pathways that affect physical exercise in schizophrenia, such as important metabolic proteins such as ApoE and ApoC, proteins involved in neuronal regulation such as tenascin and neurotrophins, neuroinflammatory regulatory pathways such as lipocalin-2 and protein 14-3-3, as well as cytoskeleton proteins of cells such as spectrins and annexines. Understanding these molecular mechanisms opens the door to future therapies in the chronicity of schizophrenia.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
3.30%
发文量
58
期刊介绍: The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
期刊最新文献
Schizophrenia and the COVID-19 pandemic: A narrative review from the biomedical perspective. Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations. Deep brain stimulation and digital monitoring for patients with treatment-resistant schizophrenia and bipolar disorder: A case series. Koro-like syndrome in Huntington's disease. Meta-analysis of the effects of adjuvant drugs in co-occurring bipolar and substance use disorder.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1