{"title":"一种测定制剂中钠啶酸含量的简单动力学方法","authors":"Murad I.H Helaleh","doi":"10.1016/S0031-6865(98)00017-X","DOIUrl":null,"url":null,"abstract":"<div><p><span>A simple selective kinetic method for the assay of nalidixic acid in solid state and pharmaceutical preparations is described. The reaction of nalidixic acid with persulfate in alkaline medium was carried out at 75°C. The correlation coefficient was found to be 1.0000. The activation parameters and the factor of the linear least square equation were calculated. The proposed method is suitable to determine nalidixic acid in the range 10–120 </span><em>μ</em>g/ml.</p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 3","pages":"Pages 157-161"},"PeriodicalIF":0.0000,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00017-X","citationCount":"1","resultStr":"{\"title\":\"A simple kinetic method for the assay of nalidixic acid in formulations\",\"authors\":\"Murad I.H Helaleh\",\"doi\":\"10.1016/S0031-6865(98)00017-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>A simple selective kinetic method for the assay of nalidixic acid in solid state and pharmaceutical preparations is described. The reaction of nalidixic acid with persulfate in alkaline medium was carried out at 75°C. The correlation coefficient was found to be 1.0000. The activation parameters and the factor of the linear least square equation were calculated. The proposed method is suitable to determine nalidixic acid in the range 10–120 </span><em>μ</em>g/ml.</p></div>\",\"PeriodicalId\":19830,\"journal\":{\"name\":\"Pharmaceutica acta Helvetiae\",\"volume\":\"73 3\",\"pages\":\"Pages 157-161\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00017-X\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutica acta Helvetiae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S003168659800017X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S003168659800017X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A simple kinetic method for the assay of nalidixic acid in formulations
A simple selective kinetic method for the assay of nalidixic acid in solid state and pharmaceutical preparations is described. The reaction of nalidixic acid with persulfate in alkaline medium was carried out at 75°C. The correlation coefficient was found to be 1.0000. The activation parameters and the factor of the linear least square equation were calculated. The proposed method is suitable to determine nalidixic acid in the range 10–120 μg/ml.
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