病态肥胖手术治疗后的代谢变化

A. A. Seypilov, E. Akhmetzhanova, K. Outlev, E. Kruchinin, I. V. Kostenko
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引用次数: 0

摘要

使用减肥手术治疗病态肥胖对代谢综合征最有效。胃内球囊和胆胰分流术后体重下降幅度最大的是前3个月,而腹腔镜下可调节胃带术后3个月至1年效果最佳。经胃内球囊治疗后,前3个月体重下降6.6%,6个月后体重下降13.5%,体重指数平均下降5.7±2.3 kg/m2。经腹腔镜可调节胃带后,3个月体重下降14.1%,6个月体重下降21.4%,1年体重指数下降27.9%,体重指数下降13.3±2.5 kg/m2。考虑到胃内球囊手术,早在球囊切除后6个月,近33%的患者恢复了初始体重,1年后,近50%的患者恢复了初始体重。需要注意的是,只有在腹腔镜胃束可调及胆胰分流术后,术后3个月,治疗1年后,观察到收缩压和舒张压以及总胆固醇和低密度脂蛋白水平的显著降低。如果身体质量指数超过50kg /m2且存在代谢综合征,胆胰分流手术也是治疗碳水化合物和脂质代谢紊乱、血压调节和其他与肥胖相关疾病的最佳选择。
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Metabolic Changes after the Surgical Treatment of Morbid Obesity
The use of bariatric surgery in the treatment of morbid obesity is most effective for metabolic syndrome. The greatest decrease in body weight occurred in the first 3 months after intragastric balloon and biliopancreatic diversion, whereas with a laparoscopic adjustable gastric band, the best effect was observed in the period from 3 months to 1 year. With an intragastric balloon, a decrease in body weight of 6.6% was observed in the first 3 months and 13.5% after 6 months, with an average decrease in body mass index of 5.7±2.3 kg/m2. After a laparoscopic adjustable gastric band, there was a 14.1% decrease in body weight at 3 months, a 21.4% decrease at 6 months, and a 27.9% decrease in body mass index at 1 year, with a 13.3±2.5 kg/m2 decrease in body mass index. Considering intragastric balloon surgery, as early as 6 months after balloon removal, almost 33% of patients showed regain of initial body weight, and 1 year later – almost 50% of patients. It should be noted only after a laparoscopic adjustable gastric band and biliopancreatic diversion, 3 months after the operation with preservation of results 1 year after treatment, a significant reduction of systolic and diastolic blood pressure and levels of total cholesterol and low-density lipoproteins was observed. If the body mass index is over 50 kg/m2 and the metabolic syndrome is present, biliopancreatic diversion surgery is the best option also for the treatment of carbohydrate and lipid metabolism disorders, blood pressure regulation, and other diseases associated with obesity.
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