抗体介导的排斥反应:一场艰苦的战斗

Chineae Journal of Organ Transplantation Pub Date : 2019-08-20 DOI:10.3760/CMA.J.ISSN.0254-1785.2019.08.001

Changxi Wang

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引用次数: 0

摘要

抗体介导的排斥反应(AMR)是影响移植肾远期存活的重要疾病，其发病机理较明确但疾病异质性高，临床表型多，尚缺乏有效的治疗手段，特别是迟发或慢性AMR。细化AMR分型有助于实施针对性治疗和预估疗效。病理诊断标准和抗体检测技术有待进一步优化，分子病理和无创监测(如供者游离DNA)能辅助提高AMR的诊断和治疗。基于HLA Eplets错配建立免疫风险分层有助于指导个体化免疫抑制方案，降低新生供者特异性抗体(DSA)风险。

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