Pub Date : 2022-10-13DOI: 10.14302/issn.2576-9359.jot-22-4303
Alireza Salmanipour, M. Ghadamzadeh, Seyed Morteza Bagheri, Roja Hajipour, Pedram Sadeghi, F. Vahedifard
Background Doppler ultrasonography can evaluate vascular and renal parenchymal disorders. In this study, color Doppler patterns in transplanted kidneys were compared with histological diagnosis to develop diagnostic models for transplanted kidney failure. Method 45 kidney transplant patients participated in this prospective study (16 suffered acute tubular necrosis (ATN), and 29 had transplant rejection). All patients had color-Doppler ultrasonography to measure kidney parameters and Doppler indices. Serum creatinine levels also assessed the transplanted kidney's function. Result Ultrasound showed a significant difference between the two groups in iliac and interlobar PSV. The ROC analysis showed a high diagnostic value of the iliac artery PSV, in distinguishing ATN from kidney transplant rejection. Serum creatinine level correlated directly with transplanted kidney volume, renal cortical thickness, and transplanted kidney length, and inversely with interlobar artery PSV and EDV. In graft rejection patients, the only significant inverse correlation was found between serum creatinine level and PSV of the iliac artery and EDV of the intrelobar artery. Discussion and conclusion The iliac artery PSV can differentiate between ATN and rejection after renal transplantation. Evaluation of renal metric parameters along with PSV and EDV of the interlobar artery (in patients with ATN) and iliac artery and interlobar artery (in transplant rejection) help determine renal dysfunction.
{"title":"Comparison the Diagnostic Value of Doppler Ultrasonography to Biopsy, in Evaluation of Post-transplant Complications and Kidney Function","authors":"Alireza Salmanipour, M. Ghadamzadeh, Seyed Morteza Bagheri, Roja Hajipour, Pedram Sadeghi, F. Vahedifard","doi":"10.14302/issn.2576-9359.jot-22-4303","DOIUrl":"https://doi.org/10.14302/issn.2576-9359.jot-22-4303","url":null,"abstract":"Background\u0000Doppler ultrasonography can evaluate vascular and renal parenchymal disorders. In this study, color Doppler patterns in transplanted kidneys were compared with histological diagnosis to develop diagnostic models for transplanted kidney failure.\u0000\u0000Method\u000045 kidney transplant patients participated in this prospective study (16 suffered acute tubular necrosis (ATN), and 29 had transplant rejection). All patients had color-Doppler ultrasonography to measure kidney parameters and Doppler indices. Serum creatinine levels also assessed the transplanted kidney's function.\u0000\u0000Result\u0000Ultrasound showed a significant difference between the two groups in iliac and interlobar PSV. The ROC analysis showed a high diagnostic value of the iliac artery PSV, in distinguishing ATN from kidney transplant rejection. Serum creatinine level correlated directly with transplanted kidney volume, renal cortical thickness, and transplanted kidney length, and inversely with interlobar artery PSV and EDV. In graft rejection patients, the only significant inverse correlation was found between serum creatinine level and PSV of the iliac artery and EDV of the intrelobar artery.\u0000\u0000Discussion and conclusion\u0000The iliac artery PSV can differentiate between ATN and rejection after renal transplantation. Evaluation of renal metric parameters along with PSV and EDV of the interlobar artery (in patients with ATN) and iliac artery and interlobar artery (in transplant rejection) help determine renal dysfunction.","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85373142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.3969/j.issn.1674-7445.2021.05.002
陈静瑜 焦国慧
Lung transplantation has been advanced for nearly half a century around the globe, and it has been developed rapidly for over 20 years in China. The field of lung transplantation in China has been gradually integrated into the international community. The outbreak of novel coronavirus pneumonia (COVID-19) in 2020 brought big challenges, as well as diverted the worldwide attention to the development of lung transplantation in China, accelerating international communication and cooperation. With the steadily deepening of clinical and basic research on lung transplantation for severe cases of COVID-19, organ transplant physicians have deepened the understanding and thinking of the maintenance of donors, selection of elderly and pediatric candidates, and perioperative management of recipients, as the future perspective of lung transplantation in China. For interdisciplinary research related to lung transplantation, it is necessary to carry out multi-center clinical trials with qualified study design and constantly promote the theoretic and practical innovation. (English) [ABSTRACT FROM AUTHOR] 肺移植技术在全球经历了近半个世纪的发展，在中国也高速发展了二十余年，中国肺移植逐渐融 入国际肺移植大家庭。2020 年新型冠状病毒肺炎（新冠肺炎）疫情暴发，既是对中国肺移植发展的挑战，也使 得全球同行关注中国肺移植发展，加速了国际间的交流与合作。随着对新冠肺炎重症患者肺移植的临床和基础 研究逐步深入，移植科医师对于未来中国肺移植在供者的维护、高龄和儿童受者的选择、围手术期管理等方面 有了更多的认知和思考。对于肺移植相关学科交叉领域的研究，需要开展设计优良、多方协作的临床试验，不 断推进学科理论和实践的创新。 (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Organ Transplantation / Qi Guan Yi Zhi is the property of Organ Transplantation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
{"title":"Development and prospect of clinical research on lung transplantation in post-COVID-19 era.","authors":"陈静瑜 焦国慧","doi":"10.3969/j.issn.1674-7445.2021.05.002","DOIUrl":"https://doi.org/10.3969/j.issn.1674-7445.2021.05.002","url":null,"abstract":"Lung transplantation has been advanced for nearly half a century around the globe, and it has been developed rapidly for over 20 years in China. The field of lung transplantation in China has been gradually integrated into the international community. The outbreak of novel coronavirus pneumonia (COVID-19) in 2020 brought big challenges, as well as diverted the worldwide attention to the development of lung transplantation in China, accelerating international communication and cooperation. With the steadily deepening of clinical and basic research on lung transplantation for severe cases of COVID-19, organ transplant physicians have deepened the understanding and thinking of the maintenance of donors, selection of elderly and pediatric candidates, and perioperative management of recipients, as the future perspective of lung transplantation in China. For interdisciplinary research related to lung transplantation, it is necessary to carry out multi-center clinical trials with qualified study design and constantly promote the theoretic and practical innovation. (English) [ABSTRACT FROM AUTHOR] 肺移植技术在全球经历了近半个世纪的发展，在中国也高速发展了二十余年，中国肺移植逐渐融 入国际肺移植大家庭。2020 年新型冠状病毒肺炎（新冠肺炎）疫情暴发，既是对中国肺移植发展的挑战，也使 得全球同行关注中国肺移植发展，加速了国际间的交流与合作。随着对新冠肺炎重症患者肺移植的临床和基础 研究逐步深入，移植科医师对于未来中国肺移植在供者的维护、高龄和儿童受者的选择、围手术期管理等方面 有了更多的认知和思考。对于肺移植相关学科交叉领域的研究，需要开展设计优良、多方协作的临床试验，不 断推进学科理论和实践的创新。 (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Organ Transplantation / Qi Guan Yi Zhi is the property of Organ Transplantation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77080759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.3969/j.issn.1674-7445.2021.04.002
孙永康 闫娟 姜峰 王惠英 马琪婼 谢颖 何湘湘 武小桐 江文诗
Objective At present, the novel coronavirus pneumonia (COVID-19) pandemic is still raging in certain regions around the globe, and the prevention and control of the pandemic should be strengthened. Under the challenges of respective social environment and allocation of medical resources, and support from the inertia and inherent productivity of the system on which the industry depends, extensive attempts are being delivered to push forward the work of organ donation and transplantation in each country. Under the guidance of national experts and committee members, Shanxi Provincial Human Organ Procurement and Allocation Service Center was established on August 28, 2018 approved by the former Shanxi Provincial Health and Family Planning Commission. It is the only independent non-profit medical institution in Shanxi Province. In this article, the system construction of citizen's organ donation and transplantation fitting national and provincial conditions was further explored according to the data analysis of organ donation and transplantation in the United States and Spain during the COVID-19 pandemic combined with the implementation of organ donation work in Shanxi Provincial Human Organ Procurement and Allocation Service Center. (English) [ABSTRACT FROM AUTHOR] 当前，新型冠状病毒肺炎（新冠肺炎）疫情全球各地形势不一，疫情防控仍然不能松懈。在面对 各自的社会环境和医疗资源配置的考验下，以及在行业赖以生存的体系运作惯性及固有生产力的支撑下，各国 器官捐献和移植工作仍在努力前行。山西省人体器官获取与分配服务中心是在国家专家委员指导下，由原山西 省卫生和计划生育委员会于 2018 年 8 月 28 日批准成立的全省唯一、独立运行的非营利性医疗机构。本文通过 剖析疫情期间美国和西班牙的器官捐献与移植数据，结合山西省人体器官获取与分配服务中心器官捐献工作的 开展情况，进一步探索符合我国国情、省情的公民器官捐献与移植工作体系的建设。 (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Organ Transplantation / Qi Guan Yi Zhi is the property of Organ Transplantation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
{"title":"Overview of global organ donation and transplantation in 2020","authors":"孙永康 闫娟 姜峰 王惠英 马琪婼 谢颖 何湘湘 武小桐 江文诗","doi":"10.3969/j.issn.1674-7445.2021.04.002","DOIUrl":"https://doi.org/10.3969/j.issn.1674-7445.2021.04.002","url":null,"abstract":"Objective At present, the novel coronavirus pneumonia (COVID-19) pandemic is still raging in certain regions around the globe, and the prevention and control of the pandemic should be strengthened. Under the challenges of respective social environment and allocation of medical resources, and support from the inertia and inherent productivity of the system on which the industry depends, extensive attempts are being delivered to push forward the work of organ donation and transplantation in each country. Under the guidance of national experts and committee members, Shanxi Provincial Human Organ Procurement and Allocation Service Center was established on August 28, 2018 approved by the former Shanxi Provincial Health and Family Planning Commission. It is the only independent non-profit medical institution in Shanxi Province. In this article, the system construction of citizen's organ donation and transplantation fitting national and provincial conditions was further explored according to the data analysis of organ donation and transplantation in the United States and Spain during the COVID-19 pandemic combined with the implementation of organ donation work in Shanxi Provincial Human Organ Procurement and Allocation Service Center. (English) [ABSTRACT FROM AUTHOR] 当前，新型冠状病毒肺炎（新冠肺炎）疫情全球各地形势不一，疫情防控仍然不能松懈。在面对 各自的社会环境和医疗资源配置的考验下，以及在行业赖以生存的体系运作惯性及固有生产力的支撑下，各国 器官捐献和移植工作仍在努力前行。山西省人体器官获取与分配服务中心是在国家专家委员指导下，由原山西 省卫生和计划生育委员会于 2018 年 8 月 28 日批准成立的全省唯一、独立运行的非营利性医疗机构。本文通过 剖析疫情期间美国和西班牙的器官捐献与移植数据，结合山西省人体器官获取与分配服务中心器官捐献工作的 开展情况，进一步探索符合我国国情、省情的公民器官捐献与移植工作体系的建设。 (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Organ Transplantation / Qi Guan Yi Zhi is the property of Organ Transplantation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75367352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-30DOI: 10.3760/CMA.J.CN421203-20200304-00056
Russell Ji, F. Huo, Jian-xiong Chen, Shao-ping Wang, Jun Liu, Yujian Zheng, Qing Cai
Objective To explore the clinical evaluation effect of COVID-19 risk assessment scale on organ donation and procurement during the epidemic of novel coronavirus pneumonia, and to reduce the incidence of donor-derived infection and medical staff infection. Method From January 20 to February 29 in 2020, the organ procurement organization of the General Hospital of Southern Theater Command adopted the COVID-19 risk assessment scale in evaluating 8 cases of potential donors. The potential donors were classified into high risk level, low risk level and uncertain risk level by analyzing the risk levels of the donation hospitals, the clinical characteristics and the exposure history of the potential donors. The coordinators, organ evaluation and ward medical staff adopted essential protective measures. The infection of COVID-19 in the above mentioned staff was observed, and the graft function and the infection of COVID-19 in the corresponding recipients were observed. Result According to the COVID-19 risk assessment results, 1 of 8 potential donors was high risk level, 5 potential donors were low risk level and 2 potential donors were uncertain risk level. 6 donors (including 5 with low risk and 1 with uncertain risk) were evaluated and underwent organ procurement. 19 grafts including liver, kidney, pancreas and heart were harvested and successfully used for organ transplantation. During the observation period of 14 days, there was no suspected or confirmed infection of COVID-19 among all coordinators and medical staff. No graft dysfunction or acute rejection was observed during the follow-up period of 4 to 30 days. No recipient was suspected or conformed to be infected with COVID-19, and 6 of them were negative for COVID-19 nucleic acid testing after organ transplantation. Conclusion During the COVID-19 epidemic, it is safe to proceed with donor organ evaluation and procurement according to the result with the COVID-19 risk assessment scale. Low-risk donor organ donation should be carried out, uncertain risk donor organ donation should be carried out cautiously, and high-risk donors should not be donated. Key words: organ transplantation; Coronavirus; Graft
{"title":"Risk assessment of organ donation and procurement during COVID-19 epidemic","authors":"Russell Ji, F. Huo, Jian-xiong Chen, Shao-ping Wang, Jun Liu, Yujian Zheng, Qing Cai","doi":"10.3760/CMA.J.CN421203-20200304-00056","DOIUrl":"https://doi.org/10.3760/CMA.J.CN421203-20200304-00056","url":null,"abstract":"Objective \u0000To explore the clinical evaluation effect of COVID-19 risk assessment scale on organ donation and procurement during the epidemic of novel coronavirus pneumonia, and to reduce the incidence of donor-derived infection and medical staff infection. \u0000 \u0000 \u0000Method \u0000From January 20 to February 29 in 2020, the organ procurement organization of the General Hospital of Southern Theater Command adopted the COVID-19 risk assessment scale in evaluating 8 cases of potential donors. The potential donors were classified into high risk level, low risk level and uncertain risk level by analyzing the risk levels of the donation hospitals, the clinical characteristics and the exposure history of the potential donors. The coordinators, organ evaluation and ward medical staff adopted essential protective measures. The infection of COVID-19 in the above mentioned staff was observed, and the graft function and the infection of COVID-19 in the corresponding recipients were observed. \u0000 \u0000 \u0000Result \u0000According to the COVID-19 risk assessment results, 1 of 8 potential donors was high risk level, 5 potential donors were low risk level and 2 potential donors were uncertain risk level. 6 donors (including 5 with low risk and 1 with uncertain risk) were evaluated and underwent organ procurement. 19 grafts including liver, kidney, pancreas and heart were harvested and successfully used for organ transplantation. During the observation period of 14 days, there was no suspected or confirmed infection of COVID-19 among all coordinators and medical staff. No graft dysfunction or acute rejection was observed during the follow-up period of 4 to 30 days. No recipient was suspected or conformed to be infected with COVID-19, and 6 of them were negative for COVID-19 nucleic acid testing after organ transplantation. \u0000 \u0000 \u0000Conclusion \u0000During the COVID-19 epidemic, it is safe to proceed with donor organ evaluation and procurement according to the result with the COVID-19 risk assessment scale. Low-risk donor organ donation should be carried out, uncertain risk donor organ donation should be carried out cautiously, and high-risk donors should not be donated. \u0000 \u0000 \u0000Key words: \u0000organ transplantation; Coronavirus; Graft","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74146272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-03DOI: 10.3760/CMA.J.CN421203-2020026-00049
L. Xia, C. Ming, Z. Wen, L. Qiu, Shuyun Xu, Tao Chen, Q. Ning, Xiaoping Luo, Zhishui Chen, N. Gong
Objective To analyze the clinical characteristics of one living-related kidney transplant recipient infected with 2019 coronavirus disease (COVID-19) . Method The clinical diagnosis and treatment of one relative renal transplant recipient after the occurrence of COVID-19 were analyzed retrospectively, including the course of onset, clinical manifestations, blood routine test, renal function, lung CT scan, nucleic acid detection, outpatient and inpatient therapies and outcomes. Result The case was diagnosed as COVID-19 (severe type) with influenza A virus infection. The clinical symptoms were gradually relieved and the lung lesions were absorbed through the treatment of reduce and stop taking immunosuppressant, antiviral therapy of abidol/oseltamivir, prevention of bacterial infection, hormone anti-inflammatory, oxygen inhalation, nutritional support and adequate rest. Conclusion This case present typical characteristics of COVID-19 in epidemiological investigation, clinical manifestation, examination, pulmonary imaging and etiology. After comprehensive treatment including reduce and stop immunosuppressive therapy, clinical cure was achieved. The long-term effect of COVID-19 on this immunosuppressive patient remains follow-up. Key words: COVID-19; living-related kidney transplantation; recipient; immunosuppression; clinical characteristics
{"title":"Clinical analysis of 2019 coronavirus disease (COVID-19) on one case with living-related kidney transplantation/ 中华器官移植杂志","authors":"L. Xia, C. Ming, Z. Wen, L. Qiu, Shuyun Xu, Tao Chen, Q. Ning, Xiaoping Luo, Zhishui Chen, N. Gong","doi":"10.3760/CMA.J.CN421203-2020026-00049","DOIUrl":"https://doi.org/10.3760/CMA.J.CN421203-2020026-00049","url":null,"abstract":"Objective \u0000To analyze the clinical characteristics of one living-related kidney transplant recipient infected with 2019 coronavirus disease (COVID-19) . \u0000 \u0000 \u0000Method \u0000The clinical diagnosis and treatment of one relative renal transplant recipient after the occurrence of COVID-19 were analyzed retrospectively, including the course of onset, clinical manifestations, blood routine test, renal function, lung CT scan, nucleic acid detection, outpatient and inpatient therapies and outcomes. \u0000 \u0000 \u0000Result \u0000The case was diagnosed as COVID-19 (severe type) with influenza A virus infection. The clinical symptoms were gradually relieved and the lung lesions were absorbed through the treatment of reduce and stop taking immunosuppressant, antiviral therapy of abidol/oseltamivir, prevention of bacterial infection, hormone anti-inflammatory, oxygen inhalation, nutritional support and adequate rest. \u0000 \u0000 \u0000Conclusion \u0000This case present typical characteristics of COVID-19 in epidemiological investigation, clinical manifestation, examination, pulmonary imaging and etiology. After comprehensive treatment including reduce and stop immunosuppressive therapy, clinical cure was achieved. The long-term effect of COVID-19 on this immunosuppressive patient remains follow-up. \u0000 \u0000 \u0000Key words: \u0000COVID-19; living-related kidney transplantation; recipient; immunosuppression; clinical characteristics","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82321323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-16DOI: 10.3760/CMA.J.ISSN.0254-1785.2020.0005
Y. Tu, Xiongfei Wu, Feng Liu, Juan Wang, Yu Luo, Zhitao Cai, Rengui Chen, Wenliang Liao, Na Liu, Jin Huang
Objective To explore the clinical features, diagnosis and prognosis of renal transplant recipients with NCP. Method The clinical data of 2 cases of kidney transplant recipients with NCP were retrospectively analyzed. Based onclinical manifestations, blood routine, inflammatory factors, cell immunity, chest CT andtherapeutic effects, the diagnosis and treatment of NCP in kidney transplant recipients (5th edition) were compared to that ofordinary NCP patients. Both recipients developed onset of low andmoderate fever, with no cough or fatigue at the initial stage. Blood routine indicated a normal range of leukocytes,buta significant decrease in lymphocyte counts, increased C-reactive protein (CRP) , and slightly higher procalcitonin (PCT) . The cellular immunity was extremely low, and the chest CT showed multiple patchy ground glass shadows in both lungs. Result After 1 week of onset, both patients had significant disease progression. The pathogenesis and imaging changes were highly similar tothatreported in ordinary NCP patients.Two patients were givensymptomatic supportive treatment by antiviral agents, stop uses ofimmunosuppression agents, small amount of hormone maintenance, intravenous drip of gamma globulin andrespiratory support toavoid secondary infections. At present, the condition of both patients is obviously improved, and renal function is stable. One of them has recovered and was discharged. Conclusion The clinical manifestations of NCP in renal transplant recipients were generally consistent with that of ordinary NCP patients. Although there is no established method for the treatment of NCP, it is effective by stopping uses of immunosuppressive agents, maintaining small and medium doses of hormones, actively restoring immunity, and providing respiratory support in a timely manner. Key words: Renal transplant; Novel coronavirus pneumonia (NCP)
{"title":"Two clinical cases of Novel coronavirus pneumonia (NCP) in renal transplant recipients/ 中华器官移植杂志","authors":"Y. Tu, Xiongfei Wu, Feng Liu, Juan Wang, Yu Luo, Zhitao Cai, Rengui Chen, Wenliang Liao, Na Liu, Jin Huang","doi":"10.3760/CMA.J.ISSN.0254-1785.2020.0005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2020.0005","url":null,"abstract":"Objective \u0000To explore the clinical features, diagnosis and prognosis of renal transplant recipients with NCP. \u0000 \u0000 \u0000Method \u0000The clinical data of 2 cases of kidney transplant recipients with NCP were retrospectively analyzed. Based onclinical manifestations, blood routine, inflammatory factors, cell immunity, chest CT andtherapeutic effects, the diagnosis and treatment of NCP in kidney transplant recipients (5th edition) were compared to that ofordinary NCP patients. Both recipients developed onset of low andmoderate fever, with no cough or fatigue at the initial stage. Blood routine indicated a normal range of leukocytes,buta significant decrease in lymphocyte counts, increased C-reactive protein (CRP) , and slightly higher procalcitonin (PCT) . The cellular immunity was extremely low, and the chest CT showed multiple patchy ground glass shadows in both lungs. \u0000 \u0000 \u0000Result \u0000After 1 week of onset, both patients had significant disease progression. The pathogenesis and imaging changes were highly similar tothatreported in ordinary NCP patients.Two patients were givensymptomatic supportive treatment by antiviral agents, stop uses ofimmunosuppression agents, small amount of hormone maintenance, intravenous drip of gamma globulin andrespiratory support toavoid secondary infections. At present, the condition of both patients is obviously improved, and renal function is stable. One of them has recovered and was discharged. \u0000 \u0000 \u0000Conclusion \u0000The clinical manifestations of NCP in renal transplant recipients were generally consistent with that of ordinary NCP patients. Although there is no established method for the treatment of NCP, it is effective by stopping uses of immunosuppressive agents, maintaining small and medium doses of hormones, actively restoring immunity, and providing respiratory support in a timely manner. \u0000 \u0000 \u0000Key words: \u0000Renal transplant; Novel coronavirus pneumonia (NCP)","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91507392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-14DOI: 10.3760/CMA.J.ISSN.0254-1785.2020.0004
T. Qiu, Jing-yu Wang, Jiangqiao Zhou, Jilin Zou, Z. Chen, Xiaoxiong Ma, Long Zhang
Objective To investigate the clinical experience of patients with novel coronavirus (2019-ncov) infection after kidney transplantation. Method Clinical data of two patients with 2019-nCoV infection after renal transplantationin Jan 2020 Renmin Hospital of Wuhan Universiyt were retrospectively analyzed.Case 1 was a 48-year-old male with CMV pneumonia secondary to 2019-nCoV infection at 4 months after transplantation. CT imaging showed multiple patchy ground-glass images of both lungs. Case 2 was a 59-year-old male, who was screened positive for 2019-nCoV nucleic acid due to fever at 9 days after renal transplantation and showed no clinical manifestations of pneumonia. After diagnosis, case 1 was transferred to a designated hospital for isolation. Treatment regimens: cefoperazone sulbactam sodium + linezolid to resist infection, gamma globulin to enhance immunity function, methylprednisolone to control inflammatory response, antiviral regimens including arbidol tablets + lopina-velitonavir tablets. Case 2 was treated with isolated treatment in a single room. The treatment plan included anti-infection (cefoperazone sulbactam sodium), enhancing immunity function (gamma globulin), antivirus therapy with arbidol and other symptomatic treatment. Result Follow up with 3 weeks, case 1 recovered with renal dysfunction, nucleic acid test with nasopharyngeal swabs turned negative, and pulmonary imaging improved. Case 2 showed no obvious clinical symptoms, and the nucleic acid test of nasopharyngeal swabs turned negative for 3 times. Conclusion Renal transplant recipients should receive fine protection to avoid exposure to high-risk environments. Diagnosis should be defined with combination of clinical manifestations, nucleic acid test and pulmonary imaging. At present, there are no antiviral drugs and symptomatic treatment is the main choice. Key words: 2019-nCov; NCP; Kidney transplant; Level III Protection
{"title":"The report of two cases infection with novel coronavirus (2019-ncov) after kidney transplantation and the association literature analyzation/ 中华器官移植杂志","authors":"T. Qiu, Jing-yu Wang, Jiangqiao Zhou, Jilin Zou, Z. Chen, Xiaoxiong Ma, Long Zhang","doi":"10.3760/CMA.J.ISSN.0254-1785.2020.0004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2020.0004","url":null,"abstract":"Objective \u0000To investigate the clinical experience of patients with novel coronavirus (2019-ncov) infection after kidney transplantation. \u0000 \u0000 \u0000Method \u0000Clinical data of two patients with 2019-nCoV infection after renal transplantationin Jan 2020 Renmin Hospital of Wuhan Universiyt were retrospectively analyzed.Case 1 was a 48-year-old male with CMV pneumonia secondary to 2019-nCoV infection at 4 months after transplantation. CT imaging showed multiple patchy ground-glass images of both lungs. Case 2 was a 59-year-old male, who was screened positive for 2019-nCoV nucleic acid due to fever at 9 days after renal transplantation and showed no clinical manifestations of pneumonia. After diagnosis, case 1 was transferred to a designated hospital for isolation. Treatment regimens: cefoperazone sulbactam sodium + linezolid to resist infection, gamma globulin to enhance immunity function, methylprednisolone to control inflammatory response, antiviral regimens including arbidol tablets + lopina-velitonavir tablets. Case 2 was treated with isolated treatment in a single room. The treatment plan included anti-infection (cefoperazone sulbactam sodium), enhancing immunity function (gamma globulin), antivirus therapy with arbidol and other symptomatic treatment. \u0000 \u0000 \u0000Result \u0000Follow up with 3 weeks, case 1 recovered with renal dysfunction, nucleic acid test with nasopharyngeal swabs turned negative, and pulmonary imaging improved. Case 2 showed no obvious clinical symptoms, and the nucleic acid test of nasopharyngeal swabs turned negative for 3 times. \u0000 \u0000 \u0000Conclusion \u0000Renal transplant recipients should receive fine protection to avoid exposure to high-risk environments. Diagnosis should be defined with combination of clinical manifestations, nucleic acid test and pulmonary imaging. At present, there are no antiviral drugs and symptomatic treatment is the main choice. \u0000 \u0000 \u0000Key words: \u00002019-nCov; NCP; Kidney transplant; Level III Protection","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83266417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.11.008
P. Wan, Ye-feng Lu, B. Qiu, M. Feng, F. Xue, Lei-Lei Xia, Yi Luo, Xiao-song Chen, Jianjun Zhang
Objective To explore the clinical efficacy of living donor liver transplantation (LDLT) for children with methylmalonic acidemia (MMA). Methods From November 2016 to April 2019, clinical data, perioperative outcomes, complications and mid-term follow-up data of 30 MMA children receiving LDLT were retrospectively analyzed. Results All recipients were vitamin B12-ineffective. There were 20 boys (66.7%) and 10 girls (33.3%) with a median age of 33(6-144) months at transplantation. And the median values of height and body weight were 87(61-137) cm and 11.0(7.0-29.0) kg respectively. The median graft-to-recipient weight ratio was 2.1% (1.0%-3.2%). All of them belonged to Child-Pugh class A. All donors were biological parents as a heterozygous carrier of pathogenic gene. Surgical complications occurred in 4 cases (13.3%), including hepatic artery thrombosis (n=1), biliary complications (n=1), hepatic vein complications (n=1) and intestinal perforation (n=1). The median follow-up period was 18(6-34) months. The posttransplant survival rates of patients and grafts were 100% and 96.3% respectively. No severe intolerable decompensated metabolic acidosis occurred after transplantation. Compared with pre-transplantation, the levels of propionylcarnitine and the ratios of propionylcarnitine to acetylcarnitine in blood and levels of methylmalonic acid and 3-hydroxypropionic acid in urine decreased markedly at 3 months post-transplantation. Conclusions LDLT using grafts from parental donors as a heterozygous carrier for MMA can significantly reduce the risks of decompensated metabolic acidosis and greatly improve the quality-of-life of children. Key words: Living donor; liver transplantation; Children; Methylmalonic acidemia
{"title":"Clinical analyses of living donor liver transplantation for methylmalonic acidemia in children","authors":"P. Wan, Ye-feng Lu, B. Qiu, M. Feng, F. Xue, Lei-Lei Xia, Yi Luo, Xiao-song Chen, Jianjun Zhang","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.11.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.11.008","url":null,"abstract":"Objective \u0000To explore the clinical efficacy of living donor liver transplantation (LDLT) for children with methylmalonic acidemia (MMA). \u0000 \u0000 \u0000Methods \u0000From November 2016 to April 2019, clinical data, perioperative outcomes, complications and mid-term follow-up data of 30 MMA children receiving LDLT were retrospectively analyzed. \u0000 \u0000 \u0000Results \u0000All recipients were vitamin B12-ineffective. There were 20 boys (66.7%) and 10 girls (33.3%) with a median age of 33(6-144) months at transplantation. And the median values of height and body weight were 87(61-137) cm and 11.0(7.0-29.0) kg respectively. The median graft-to-recipient weight ratio was 2.1% (1.0%-3.2%). All of them belonged to Child-Pugh class A. All donors were biological parents as a heterozygous carrier of pathogenic gene. Surgical complications occurred in 4 cases (13.3%), including hepatic artery thrombosis (n=1), biliary complications (n=1), hepatic vein complications (n=1) and intestinal perforation (n=1). The median follow-up period was 18(6-34) months. The posttransplant survival rates of patients and grafts were 100% and 96.3% respectively. No severe intolerable decompensated metabolic acidosis occurred after transplantation. Compared with pre-transplantation, the levels of propionylcarnitine and the ratios of propionylcarnitine to acetylcarnitine in blood and levels of methylmalonic acid and 3-hydroxypropionic acid in urine decreased markedly at 3 months post-transplantation. \u0000 \u0000 \u0000Conclusions \u0000LDLT using grafts from parental donors as a heterozygous carrier for MMA can significantly reduce the risks of decompensated metabolic acidosis and greatly improve the quality-of-life of children. \u0000 \u0000 \u0000Key words: \u0000Living donor; liver transplantation; Children; Methylmalonic acidemia","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82424191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.11.006
Ying Wang, Yingdong Du, Jianxiu Yu, Hao Zhang, Wei Wu, Luyang Jiang, Liang Zhao, Qian Yang
Objective To assess the impact of multiple sessions of transarterial chemoembolization (TACE) on tumor necrosis, tumor recurrence and survival in patients awaiting liver transplantation (LT). Methods From January 2003 to December 2012, retrospective analysis was performed for 84 LT patients receiving TACE for HCC. The median follow-up period was 76(0-146) months. Results Among them, 9/84 LT patients (10.7%) developed recurrent HCC. Recurrence had a significant relationship with a short interval between the diagnosis of HCC and LT (<6 months) [P=0.029, odds ratio (OR)=19.2]. No significant relationship existed between tumor necrosis in explant and recurrence. The mean overall survival was 102.8 months (95% confidence interval 594.9-110.8 months) and the 1/3/5-year survival rates were 91.7%, 88.1% and 82.1% respectively. Waiting time <6 months, microvascular invasion and tumor characteristics were statistically associated with shorter survival. The session number of TACE was not associated with tumor necrosis or survival. Conclusions Multiple sessions of TACE are not associated with a higher risk of recurrence or shorter survival. A shorter waiting time before LT is correlated with an elevated risk of recurrence and lowered survival after LT for HCC. Key words: Transarterial chemoembolization (TACE); Hepatocellular carcinoma; Liver transplantation
{"title":"Impact of multiple sessions of transarterial chemoembolization for hepatocellular carcinoma patients awaiting liver transplantation","authors":"Ying Wang, Yingdong Du, Jianxiu Yu, Hao Zhang, Wei Wu, Luyang Jiang, Liang Zhao, Qian Yang","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.11.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.11.006","url":null,"abstract":"Objective \u0000To assess the impact of multiple sessions of transarterial chemoembolization (TACE) on tumor necrosis, tumor recurrence and survival in patients awaiting liver transplantation (LT). \u0000 \u0000 \u0000Methods \u0000From January 2003 to December 2012, retrospective analysis was performed for 84 LT patients receiving TACE for HCC. The median follow-up period was 76(0-146) months. \u0000 \u0000 \u0000Results \u0000Among them, 9/84 LT patients (10.7%) developed recurrent HCC. Recurrence had a significant relationship with a short interval between the diagnosis of HCC and LT (<6 months) [P=0.029, odds ratio (OR)=19.2]. No significant relationship existed between tumor necrosis in explant and recurrence. The mean overall survival was 102.8 months (95% confidence interval 594.9-110.8 months) and the 1/3/5-year survival rates were 91.7%, 88.1% and 82.1% respectively. Waiting time <6 months, microvascular invasion and tumor characteristics were statistically associated with shorter survival. The session number of TACE was not associated with tumor necrosis or survival. \u0000 \u0000 \u0000Conclusions \u0000Multiple sessions of TACE are not associated with a higher risk of recurrence or shorter survival. A shorter waiting time before LT is correlated with an elevated risk of recurrence and lowered survival after LT for HCC. \u0000 \u0000 \u0000Key words: \u0000Transarterial chemoembolization (TACE); Hepatocellular carcinoma; Liver transplantation","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89729697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis and treatment of vascular complications after liver transplantation","authors":"Zhihui Wang","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.11.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.11.001","url":null,"abstract":"肝移植是治疗终末期肝病最有效的方法，术后血管并发症是导致移植物丢失和受者死亡的重要原因。本文从肝移植术后血管并发症的危险因素、影像学检查和治疗选择等方面概述血管并发症的诊断和治疗，旨在提高肝移植疗效。","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87418388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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