MicroRNA-203 通过靶向 PIBF1/Akt 信号抑制胃癌生长

IF 0.8 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY Materials Science-medziagotyra Pub Date : 2016-03-15 DOI:10.1186/s13046-016-0323-1

Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang, Jin-Shui Zhu

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引用次数: 0

摘要

背景：微RNA（miRNA）已被证实参与了包括肿瘤生长在内的多种致瘤行为。但是，miRNA-203 在胃癌（GC）中的临床意义和功能仍然难以确定：结果：miRNA-203 的表达减少与胃癌患者的肿瘤大小、预后不良和复发有关。过表达 miR-203 或敲除其靶标孕酮免疫调节结合因子 1（PIBF1）可抑制 GC 在体外和体内的生长，而敲除 miR-203 则可促进 GC 的增殖。此外，PIBF1的过表达削弱了miR-203对GC生长的抑制作用，并增强了对p-Akt表达的影响：结论：MiR-203作为一种肿瘤生物标记物，通过靶向PIBF1/Akt信号传导抑制GC生长，这表明它在治疗GC方面可能具有重要的治疗潜力。

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MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling.

Background: MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive.

Results: Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression.

Conclusions: MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.

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来源期刊

Materials Science-medziagotyra 工程技术-材料科学：综合

CiteScore

1.70

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： It covers the fields of materials science concerning with the traditional engineering materials as well as advanced materials and technologies aiming at the implementation and industry applications. The variety of materials under consideration, contributes to the cooperation of scientists working in applied physics, chemistry, materials science and different fields of engineering.