Acute and subacute oral toxicity study of Rasa chenduram

Back ground: Rasa chenduram is one of the siddha shastricherbomineral formulation containing Rasam [hydragyram], Gandhagam [sulphur], and aridharam [arsenic trisulphide] were indicated for many chronic skin diseases like parangisogai, kiranthi, kuttarogam, thaadhunattam, lingaputtru, vippuruthi from the classical text pulippanivaidhiyam undergone preclinical study and clinical study with the approval from iec committee from our institution. Materials and methods: Acute oral toxicity 423 and sub acute oral toxicity studies 407 were carried out in wister albino rats of body weight 150-200 gms of 6-8 weeks with the proper approval from IAEC committee. Conclusion: this study reveals the oral administration of rasa chenduram in wister albino rats with the dose of 9mg/kg body weight showed no significant changes in haematological, pathological, behavioural movements.