肌萎缩侧索硬化的发病机制

M. Kuźma-Kozakiewicz
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引用次数: 56

摘要

肌萎缩侧索硬化症是一种影响上下运动神经元的破坏性神经退行性疾病。尽管进行了广泛的研究,但该疾病的主要原因尚未确定,也缺乏病因治疗。本文描述了疾病发生和发展的机制,包括氧化应激、兴奋毒性、线粒体功能障碍、蛋白质聚集、RNA加工、细胞骨架功能和轴突运输的改变、胶质细胞的参与和程序性细胞死亡。生物医学评论2011;22日:7 - 14。
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Pathogenesis of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease affecting both upper and lower motor neuron. Despite extensive research the primary cause of the disease has not been indentified and the causative treatment is lacking. The present article describes mechanisms involved in the disease development and progression, including oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, RNA processing, alterations of cytoskeleton functions and axonal transport, glial cell involvement and programmed cell death. Biomedical Reviews 2011; 22: 7-14.
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