片剂剂型中驱虫剂含量新分析方法的建立与验证

S. Patharkar, K. Gajbhiye, Nawaz Hakam, AM. Vyawahare
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引用次数: 2

摘要

反相高效液相色谱法快速、灵敏、准确地测定片剂剂型中抗组胺含量。流动相为甲醇:0.1%邻位磷酸(80:20% v/v)。流速0.9 ml/min。检测波长为227 nm。进样量为20µl。该方法的选择性、精密度、线性度和准确度均得到了验证。所有验证参数均在可接受范围内。左旋咪唑(10 ~ 60µg/ml)呈线性关系。准确度的RSD小于2%。左旋咪唑的线性范围为10 ~ 60µg /ml。选取回收率研究的80%、100%和120%水平进行回收率研究。左旋咪唑浓度为(10-60µg /ml)时进行线性研究。
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Development and Validation of New Analytical Method for Estimation of Anthelmintic in Tablet Dosage Form
A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1% Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9 ml/min. The detection Wavelength was 227 nm. The injection volume was 20-µl. The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Levamisole was performed (10-60µg/ml). The %RSD for accuracy found to be less than2%. Assay was found to be 99.17 to 101.65 respectively The range of 10-60µg /ml was selected for the linearity of a standard Levamisole. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study. Linearity studies for Levamisole was performed on (10-60µg /ml).
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