表观遗传机制在各种癌症治疗中的作用

Rinki Yadav, Ashish K. Srivastava, S. Chandra, A. Rai
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引用次数: 3

摘要

表观遗传学不仅在细胞的正常功能及其发育中发挥作用,而且在神经系统疾病和癌症等疾病中也发挥作用。表观遗传疗法可以帮助解决这些病理生理条件的不相同的问题。癌症是一种具有遗传和表观遗传起源的复杂疾病。表观遗传学在癌症中的重要性已被确定,近年来该领域迅速兴起。表观遗传和遗传改变有助于癌症的发生和发展。表观遗传修饰引起遗传改变,通常发生在肿瘤发展的早期阶段,但也可能与肿瘤的侵袭和扩散有关。近年来遗传学和表观遗传学的研究进展使我们对人类肿瘤发生和发展过程中潜在的表观遗传学改变有了更好的了解。
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Role of epigenetic mechanisms in various cancer therapies
Epigenetics play a role not just in the normal functioning of the cell and its development, but also in diseases like neurological diseases and cancer. Epigenetic therapies can help to resolve non-identical problems of these pathophysiological conditions. Cancer is a complex disease with both genetic and epigenetic origins. The importance of epigenetics in cancer has been identified, and the field has emerged rapidly in recent years. Epigenetic and genetic alterations contribute to the initiation and progression of cancer. Epigenetic modifications introduced genetic changes, and usually occur at an early stage in development of a neoplasm, but may also be involved in its invasion and spread. Recent technological advances in genetics and epigenetics offer a better understanding of the underlying epigenetic alterations during initiation and in the progression process of the human tumors.
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