{"title":"基于离子电流整流的pH响应纳米探针的制备与表征","authors":"M. Şen","doi":"10.1109/BIYOMUT.2016.7849376","DOIUrl":null,"url":null,"abstract":"In this study, we investigated the ionic current rectification of glass nanopipettes modified with bovine serum albumin - glutaraldehyde (BSA-GA) artificial membrane using solutions with various pHs. Ionic current rectification is a phenomenon that is observed with nanopores as asymmetric I-V curves, where the ionic currents recorded through a nanopore differ at the same magnitude of applied electrical potentials biased with opposite polarities. The results clearly showed that modifying the tip of a nanopipette results in a pH dependent ionic current behavior. The proposed strategy is a facile method for fabrication of a pH responsive nanoprobe that has a potential for intracellular pH measurement.","PeriodicalId":8439,"journal":{"name":"arXiv: Chemical Physics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Fabrication and characterization of pH responsive nanoprobes based on ion current rectification\",\"authors\":\"M. Şen\",\"doi\":\"10.1109/BIYOMUT.2016.7849376\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, we investigated the ionic current rectification of glass nanopipettes modified with bovine serum albumin - glutaraldehyde (BSA-GA) artificial membrane using solutions with various pHs. Ionic current rectification is a phenomenon that is observed with nanopores as asymmetric I-V curves, where the ionic currents recorded through a nanopore differ at the same magnitude of applied electrical potentials biased with opposite polarities. The results clearly showed that modifying the tip of a nanopipette results in a pH dependent ionic current behavior. The proposed strategy is a facile method for fabrication of a pH responsive nanoprobe that has a potential for intracellular pH measurement.\",\"PeriodicalId\":8439,\"journal\":{\"name\":\"arXiv: Chemical Physics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv: Chemical Physics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BIYOMUT.2016.7849376\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv: Chemical Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIYOMUT.2016.7849376","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Fabrication and characterization of pH responsive nanoprobes based on ion current rectification
In this study, we investigated the ionic current rectification of glass nanopipettes modified with bovine serum albumin - glutaraldehyde (BSA-GA) artificial membrane using solutions with various pHs. Ionic current rectification is a phenomenon that is observed with nanopores as asymmetric I-V curves, where the ionic currents recorded through a nanopore differ at the same magnitude of applied electrical potentials biased with opposite polarities. The results clearly showed that modifying the tip of a nanopipette results in a pH dependent ionic current behavior. The proposed strategy is a facile method for fabrication of a pH responsive nanoprobe that has a potential for intracellular pH measurement.
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