用硅结构相似性方法鉴定蒽醌类分子作为c-myc g -四重诱导剂/稳定剂

V. P. Ma, W. Lam, Dik‐Lung Ma, C. Leung
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引用次数: 0

摘要

蒽醌衍生物等中药天然产物具有多种药理特性,并被证明具有很高的疗效。之前,我们的小组报道了蒽醌衍生物Fonsecin B作为c-myc - g四联稳定剂。本文报道了两种在中药材大黄中含有可修饰羟基的生物活性蒽醌,它们是c-myc g -四联体稳定剂,通过硅结构相似性方法进行了鉴定。用PCR停止法研究蒽醌类与c-myc g -四重体的相互作用
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Hit identification of anthraquinone based molecules as c-myc G-quadruplex inducers/stabilizers via in silico structural similarity approach
Natural products in Traditional Chinese Medicine (TCM) such as anthraquinone derivatives have a wide variety of pharmacological properties as well as proven record of high efficacy. Previously, our group reported an anthraquinone derivative Fonsecin B as c-myc G-quadruplex stabilizer. We herein report two bioactive anthraquinones with modifiable hydroxyl groups abundant in Chinese Medicine Rheum Palmatum L. (also known as Da Huang) as c-myc G-quadruplex stabilizer, identified by in silico structural similarity approach. Interaction of the anthraquinones with c-myc G-quadruplex was investigated by PCR Stop Assay
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