紫杉醇致脊髓运动神经元病变的超微结构矫正

M. Ostrovskyi
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摘要

背景。紫杉醇诱导的周围神经病变(PIPN)是紫杉醇在癌症患者中的主要副作用,其机制尚不完全清楚。本研究旨在探讨PIPN联合2-乙基-6-甲基-3-琥珀酸羟吡啶给药对脊髓前角神经元精细亚显微结构的影响。方法。实验用80只大鼠进行腹腔注射紫杉醇(Actavis,罗马尼亚),紫杉醇预溶于等渗盐水中,剂量为2 mg / kg体重,每天4次,达到8 mg / kg。48只大鼠按10 mg / kg的剂量腹腔注射2-乙基-6-甲基-3-琥珀酸羟吡啶(32只大鼠腹腔注射用水)。观察期分别为1、7、14、21、28 d。结果。我们发现2-乙基-6-甲基-3-羟基吡啶纠正了脊髓运动神经元的形态功能状态,并对它们显示出积极的代谢作用。结论。这表现在负责蛋白质合成(颗粒内质网、核糖体和多体)、呼吸(线粒体)和保护(溶酶体)功能的神经元结构的电镜图像的改善上。
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Correction of ultrastructural paclitaxel-induced spinal cord motoneurons lesions
Background. Paclitaxel-induced peripheral neuropathy (PIPN) is a major side effect of paclitaxel in patients with cancer with no fully known mechanisms. The aim of the study was to investigate the fine sub-microscopic structure of the spinal cord anterior horn neurons in PIPN combined with 2-ethyl-6-methyl-3-hydroxypyridine succinate administration. Methods. The experiment was performed on 80 white rats, which were administered intraperitoneally with Paclitaxel (Actavis, Romania), pre-dissolved in an isotonic saline at a dose of 2 mg / kg body weight four times a day to achieve a dose of 8 mg / kg. Then 48 of these animals were injected intraperitoneally 2-ethyl-6-methyl-3-hydroxypyridine succinate at a dose of 10 mg / kg (32 rats received intraperitoneally water for injection). Observation periods were 1, 7, 14, 21, 28 days. Results. We found that 2-ethyl-6-methyl-3-hydroxypyridine corrects the morpho-functional state of the motor neurons of the spinal cord and revealed a positive metabolic effect on them. Conclusion. This was manifested by the improvement of the electron microscopic picture of the neuronal structures responsible for their protein-synthetic (granular endoplasmic reticulum, ribosomes and polysomes), respiratory (mitochondria), and protective (lysosomes) functions.
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