{"title":"饮食缺铜后雄性 Wistar 脑亚区域的蛋白质羰基、脂质过氧化、谷胱甘肽和酶抗氧化状态","authors":"Ankita Rajendra Kurup, Neena Nair","doi":"10.1007/s12291-022-01093-1","DOIUrl":null,"url":null,"abstract":"<p><p>Copper a quintessential transitional metal is required for development and function of normal brain and its deficiency has been associated with impairments in brain function. The present study investigates the effects of dietary copper deficiency on brain sub-regions of male Wistar rats for 2-, 4- and 6-week. Pre-pubertal rats were divided into four groups: negative control (NC), copper control (CC), pairfed (PF) and copper deficient (CD). In brain sub regions total protein concentration, glutathione concentration and Cu-Zn SOD activity were down regulated after 2-, 4- and 6 weeks compared to controls and PF groups. Significant increase in brain sub regions was observed in protein carbonyl and lipid peroxidation concentration as well as total SOD, Mn SOD and catalase activities after 2-, 4- and 6 weeks of dietary copper deficiency. Experimental evidences indicate that impaired copper homeostasis has the potential to generate reactive oxygen species enhancing the susceptibility to oxidative stress by inducing up- and down-regulation of non-enzymatic and enzymatic profile studied in brain sub regions causing loss of their normal function which can consequently lead to deterioration of cell structure and death if copper deficiency is prolonged.</p>","PeriodicalId":54878,"journal":{"name":"Journal of Approximation Theory","volume":"2 1","pages":"73-82"},"PeriodicalIF":0.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784247/pdf/","citationCount":"0","resultStr":"{\"title\":\"Protein Carbonyl, Lipid Peroxidation, Glutathione and Enzymatic Antioxidant Status in Male Wistar Brain Sub-regions After Dietary Copper Deficiency.\",\"authors\":\"Ankita Rajendra Kurup, Neena Nair\",\"doi\":\"10.1007/s12291-022-01093-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Copper a quintessential transitional metal is required for development and function of normal brain and its deficiency has been associated with impairments in brain function. The present study investigates the effects of dietary copper deficiency on brain sub-regions of male Wistar rats for 2-, 4- and 6-week. Pre-pubertal rats were divided into four groups: negative control (NC), copper control (CC), pairfed (PF) and copper deficient (CD). In brain sub regions total protein concentration, glutathione concentration and Cu-Zn SOD activity were down regulated after 2-, 4- and 6 weeks compared to controls and PF groups. Significant increase in brain sub regions was observed in protein carbonyl and lipid peroxidation concentration as well as total SOD, Mn SOD and catalase activities after 2-, 4- and 6 weeks of dietary copper deficiency. Experimental evidences indicate that impaired copper homeostasis has the potential to generate reactive oxygen species enhancing the susceptibility to oxidative stress by inducing up- and down-regulation of non-enzymatic and enzymatic profile studied in brain sub regions causing loss of their normal function which can consequently lead to deterioration of cell structure and death if copper deficiency is prolonged.</p>\",\"PeriodicalId\":54878,\"journal\":{\"name\":\"Journal of Approximation Theory\",\"volume\":\"2 1\",\"pages\":\"73-82\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784247/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Approximation Theory\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://doi.org/10.1007/s12291-022-01093-1\",\"RegionNum\":3,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/10/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATHEMATICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Approximation Theory","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1007/s12291-022-01093-1","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/10/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATHEMATICS","Score":null,"Total":0}
Protein Carbonyl, Lipid Peroxidation, Glutathione and Enzymatic Antioxidant Status in Male Wistar Brain Sub-regions After Dietary Copper Deficiency.
Copper a quintessential transitional metal is required for development and function of normal brain and its deficiency has been associated with impairments in brain function. The present study investigates the effects of dietary copper deficiency on brain sub-regions of male Wistar rats for 2-, 4- and 6-week. Pre-pubertal rats were divided into four groups: negative control (NC), copper control (CC), pairfed (PF) and copper deficient (CD). In brain sub regions total protein concentration, glutathione concentration and Cu-Zn SOD activity were down regulated after 2-, 4- and 6 weeks compared to controls and PF groups. Significant increase in brain sub regions was observed in protein carbonyl and lipid peroxidation concentration as well as total SOD, Mn SOD and catalase activities after 2-, 4- and 6 weeks of dietary copper deficiency. Experimental evidences indicate that impaired copper homeostasis has the potential to generate reactive oxygen species enhancing the susceptibility to oxidative stress by inducing up- and down-regulation of non-enzymatic and enzymatic profile studied in brain sub regions causing loss of their normal function which can consequently lead to deterioration of cell structure and death if copper deficiency is prolonged.
期刊介绍:
The Journal of Approximation Theory is devoted to advances in pure and applied approximation theory and related areas. These areas include, among others:
• Classical approximation
• Abstract approximation
• Constructive approximation
• Degree of approximation
• Fourier expansions
• Interpolation of operators
• General orthogonal systems
• Interpolation and quadratures
• Multivariate approximation
• Orthogonal polynomials
• Padé approximation
• Rational approximation
• Spline functions of one and several variables
• Approximation by radial basis functions in Euclidean spaces, on spheres, and on more general manifolds
• Special functions with strong connections to classical harmonic analysis, orthogonal polynomial, and approximation theory (as opposed to combinatorics, number theory, representation theory, generating functions, formal theory, and so forth)
• Approximation theoretic aspects of real or complex function theory, function theory, difference or differential equations, function spaces, or harmonic analysis
• Wavelet Theory and its applications in signal and image processing, and in differential equations with special emphasis on connections between wavelet theory and elements of approximation theory (such as approximation orders, Besov and Sobolev spaces, and so forth)
• Gabor (Weyl-Heisenberg) expansions and sampling theory.