脂质体在抗肿瘤领域的研究进展

Xiaochuan Xu
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引用次数: 0

摘要

脂质体作为一种具有生物相容性、表面易于修饰的安全纳米载体,在抗肿瘤领域有着广阔的应用前景。它们的靶向性有助于减少药物剂量和非靶细胞毒性。为了进一步开发脂质体的靶向性,通过表面修饰构建了被动靶向脂质体、主动靶向脂质体和物化靶向脂质体。本文综述了不同类型靶向脂质体的作用机制,阐述了脂质体在克服肿瘤耐药、免疫治疗和帮助药物穿过血脑屏障等方面的具体作用,并总结了目前的发展问题和未来的发展方向。
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Advances in liposome research in the field of antitumor
Liposomes, as biocompatible and safe nanocarriers with easily modified surfaces, can be well used in the field of antitumor. Their targeting properties have contributed to the reduction of drug dosage and non-target cell toxicity. To further exploit the targeting properties of liposomes, passive targeting liposomes, active targeting liposomes and physicochemical targeting liposomes have been constructed by surface modification. This paper summarizes the mechanisms of action of different types of targeted liposomes and describes the specific role of liposomes in overcoming tumor resistance, immunotherapy and helping drugs to cross the blood-brain barrier, and summarizes the current development issues and future directions.
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