鼻腔给药系统研究进展综述

Akash H. Mali, Azam Z. Shaikh
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引用次数: 1

摘要

鼻给药作为一种方便、可靠、有发展前景的全身给药方法受到了广泛的关注。特别适用于那些口服无效,只有通过注射才能有效的分子。鼻给药途径比其他可选择的给药系统有优势。本文就鼻给药系统的局限性、优势、药物吸收机制、鼻解剖与生理、影响鼻给药的因素、药物分布与沉积、鼻给药系统面临的挑战与机遇等方面进行综述。这些给药系统有能力控制药物从鼻腔的清除率,并保护药物在鼻腔分泌物中不被酶降解。
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A Short Review on Nasal Drug Delivery System
Nasal drug delivery has received a great deal of attention as convenient, reliable and promising methods for the systemic administration of drug. It is especially for those molecules which are ineffective oraly and only effective if administration by injection. The nasal route of drug delivery has advantage over the other alternative system of drug administration. The present review is an attempt to provide some information concerning nasal drug delivery system such as limitation, advantage, mechanism drug absorption, anatomy and Physiology Nasal, factor affecting of nasal drug delivery, drug distribution and deposition, Challenges and oppurtunities for Nasal Delivery Systems1. These drug delivery system have the ability to control the rate of drug clearance from the nasal cavity as well as protect the drug from enzymatic degradation in nasal secretions2..
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