古吉拉特邦一家三级医疗机构分离的肠杆菌科细菌的抗菌敏感性模式

Jagruti C. Patel, J. Bhatt, V. A. Javiya, Kamlesh Patel
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引用次数: 12

摘要

目的:本研究旨在评估印度古吉拉特邦一家三级医院肠杆菌科细菌的抗生素敏感性。方法:276份培养阳性标本中,检测肠杆菌科154份,收集11种不同类型标本。微生物敏感性试验采用大肠杆菌NCTC 10418纸片扩散试验,按照CLSI指南。结果:尿中肠杆菌感染率最高,其次为脓和痰。肠杆菌对青霉素和头孢菌素的单一治疗表现出明显的耐药性。氨苄西林、阿莫西林和第三代头孢菌素联合舒巴坦和阿米卡星单药对肠杆菌感染的敏感性较高,但碳青霉烯类药物的敏感性最高。结论:尿路感染是最常见的医院获得性感染。同时给药-内酰胺酶抑制剂可显著提高青霉素类和头孢菌素类药物的抗菌敏感性。阿米卡星和碳青霉烯类药物的使用应仅限于严重的医院感染,以避免耐药菌株的迅速出现。
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Anti-Microbial Susceptibility Patterns of Enterobacteriaceae Isolated From A Tertiary Care Unit In Gujarat
Objectives: Present study was undertaken to assess antibiotic susceptibility patterns of Enterobacteriaceae at a tertiary care hospital in Gujarat, India. Methods: Out of 276 culture positive samples, 154 samples of Enterbacteriaceae were examined and 11 different types of specimen were collected. Microbial sensitivity testing was done using disk diffusion test with Escherichia coli NCTC 10418 as per CLSI guidelines. Results: Highest Enterobacteriacae infections were found in urine followed by pus and sputum. Enterobacteriacae species demonstrated marked resistance against monotherapy of penicillins and cephalosporins. Combination of ampicillin, amoxicillin and third generation cephalosporins with sulbactam and monotherapy of amikacin showed higher sensitivity to Enterobacteriacae infections but maximum sensitivity was shown by carbapenems. Conclusions: Urinary tract infection was the most common hospital acquired infection. Co-administration of -lactamase inhibitor markedly expanded the anti-microbial sensitivity of penicillins and cephalosporins. Use of amikacin and carbapenems should be restricted to severe nosocomial infections to avoid rapid emergence of resistant strains.
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