用近红外反射光谱法实时监测固相合成中的非破坏性反应-树脂结合醇的酯化反应

Analytical Communications Pub Date : 1999-01-01 DOI:10.1039/A900747D

Jonathan Hammond, A. Moffat, R. D. Jee, B. Kellam

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引用次数: 10

摘要

近红外(NIR)反射光谱已被用于监测树脂结合官能团的化学相互转化。测量不需要样品制备，直接通过玻璃反应容器的底部进行。用乙酸酐在甲苯介质中酯化树脂结合醇的时间-浓度曲线。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy—esterification of a resin-bound alcohol

Near-infrared (NIR) reflectance spectroscopy has been used to monitor the chemical inter-conversion of resin-bound functional groups. Measurements required no sample preparation and were made directly through the bottom of the glass reaction vessel. The time–concentration profile of the esterification of a resin-bound alcohol by acetic anhydride in a toluene medium is demonstrated.

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Analytical Communications

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