The analysis of pathological features of gastritis and Helicobacter pylori infection

[Objective] To explore the correlation between helicobacter pylori infection and several pathological features of gastritis, and provide evidence for pathological features analysis and diagnosis in helicobacter pylori associated gastritis. [Methods] We collected 180 patients with gastritis admitted to the Seventh Affiliated Hospital of Sun Yat-sen University from 2021 to 2022, and make a retrospective analysis of their status of H. pylori with PCR technology. Then we further detected the resistant results of clarithromycin and fluoroquinolone in H. pylori positive group. Chi-Squared Test were used to analyzed the relationship between helicobacter pylori status and pathological features of gastritis. [Results] Erosion or ulcers in the H. pylori-positive group were significantly higher than those in the H. pylori-negative group (P<0.05). Meanwhile, H. pylori-positive group were tended to have more severe activity or inflammation in the biopsy specimen. However, there was no significant difference in resistance to clarithromycin or fluoroquinolone in H. pylori-positive group with erosion, ulcers, or active inflammation. [Conclusion] Helicobacter pylori infection is correlated with gastritis pathological features such as erosion, ulcers, inflammation or activity, but the pathological features of H. pylori-positive patients could not predict the antibiotic resistance. The experiment of screening drug resistance still has important clinical significance.