新佛州巴哈市首次出现COVID-19死亡病例:经验教训

Shu Ann Hon, Lian Thai Lee, Qin Jian Low
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引用次数: 0

摘要

2019冠状病毒病于2020年3月11日被宣布为全球大流行。本病例报告是关于COVID-19(冠状病毒-19)引起的严重急性呼吸道感染(SARI)。一位68岁的女性,伴有高血压和充血性心力衰竭,表现为发热和咳咳5天。在她发表演讲的前一周,她曾前往柔佛州的Kluang参加一个婚礼聚会,后来发现这是导致COVID-19聚集性病例的原因。除此之外,她否认有任何生病或已知的COVID-19接触。呼吸检查显示左下区震颤。到达医院时,她呼吸急促,戴着15升高流量面罩,血压降(血压90/70毫米汞柱)。胸片显示双侧不对称实变。她有淋巴细胞减少,而登革热血清学结果为阴性。她被诊断为继发于肺炎的急性呼吸道感染并感染性休克,由于呼吸衰竭需要机械通气。入院第3天用鼻咽拭子检出SARS - CoV-2(严重急性呼吸综合征冠状病毒-2)阳性。除了支持性和重症监护措施外,在此期间,根据当地指南,她开始口服羟氯喹、皮下干扰素β和糖浆洛匹那韦/利托那韦。不幸的是,她在入院第3天出现急性呼吸窘迫综合征(ARDS),并因呼吸衰竭而去世。临床医生应关注COVID-19危重疾病概况和死亡风险。通过对高危患者的早期识别,可以对医疗资源进行有组织、及时的管理,提高医疗服务的效果。
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The First COVID-19 Mortality in Batu Pahat, Johor: Lesson Learnt
COVID-19 had been declared as a global pandemic on 11 March 2020. This case report is about Severe Acute Respiratory Infection (SARI) due to COVID-19 (Corona Virus-19). A 68-yearold lady with underlying hypertension and congestive cardiac failure presented with fever and productive cough for 5 days duration. One week before her presentation, she had travelled to Kluang, Johor for a wedding gathering which was later found to have contributed to a cluster of COVID-19 cases. Otherwise, she denied any sick or known COVID-19 contact. Respiratory examination revealed left lower zonecrepitations. She was tachypnoeic on a high flow mask 15 L and hypotensive (BP 90/70 mm Hg) on arrival at the hospital. Chest radiograph showed bilateral asymmetrical consolidations. There was a presence of lymphopenia while her dengue serology result was negative. She was treated as SARI secondary to pneumonia with septic shock and required mechanical ventilation due to respiratory failure. Nasopharyngeal swab for SARS CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2) was taken as positive for COVID-19 on the third day of admission. Apart from supportive andintensive care measures, she was commenced on oral hydroxychloroquine, subcutaneous Interferon Beta and syrup lopinavir/ritonavir per local guidelines during that period. Unfortunately, she developed acute respiratory distress syndrome (ARDS) on day 3 of admission and passed away due to respiratory failure. Clinicians should pay attention to the COVID-19 critical disease profile and mortality risks. By identifying high-risk patients early, medical resources can be administered in an organized way and timely way to improve the efficacy of the healthcare services.
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