大肠杆菌中lac操纵子的有限状态机和马尔可夫等价

IF 1 Q4 ENGINEERING, BIOMEDICAL AIMS Bioengineering Pub Date : 2022-01-01 DOI:10.3934/bioeng.2022029
Urooj Ainuddin, Maria Waqas
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引用次数: 0

摘要

计算生物学家对大肠杆菌中的lac操纵子进行了广泛的研究。细菌利用它在没有葡萄糖的情况下生存,利用乳糖生长。本文提出了一种新的乳糖操纵子建模机制,将乳糖代谢过程从细胞转移到有限状态机(FSM)。该FSM在现场可编程门阵列(FPGA)中实现,并在随机条件下进行了仿真。对于lac操纵子,本文还提出了一个马尔可夫链,这有助于从概率变量的角度研究其行为,同时验证有限状态机。这项工作的重点是将生物过程转化为计算机器。
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Finite state machine and Markovian equivalents of the lac Operon in E. coli bacterium

The lac operon in E. coli has been extensively studied by computational biologists. The bacterium uses it to survive in the absence of glucose, utilizing lactose for growth. This paper presents a novel modeling mechanism for the lac operon, transferring the process of lactose metabolism from the cell to a finite state machine (FSM). This FSM is implemented in field-programmable gate array (FPGA) and simulations are run in random conditions. A Markov chain is also proposed for the lac operon, which helps study its behavior in terms of probabilistic variables, validating the finite state machine at the same time. This work is focused towards conversion of biological processes into computing machines.

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来源期刊
AIMS Bioengineering
AIMS Bioengineering ENGINEERING, BIOMEDICAL-
自引率
0.00%
发文量
17
审稿时长
4 weeks
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