Aleksandra Klisić, Irena Radoman-Vujačić, Jelena Kostadinović, Ana Ninić
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引用次数: 1
摘要
背景:据我们所知,绝经后妇女的各种代谢和肾脏生物标志物与维生素 D(以 25- 羟基维生素 D [25(OH)D]测定)之间的相互关系尚未得到研究。因此,我们旨在通过全面的多标志物统计方法来探讨这种关系:方法:共纳入 150 名绝经后妇女(无糖尿病和心血管疾病)。测量了人体测量和生化指标。计算脂肪肝指数(FLI)和胰岛素抵抗稳态模型评估(HOMA-IR)。采用单变量和多变量二元逻辑回归分析来检验[25(OH)D]状态对心脏代谢指标的预测。主成分分析(PCA)用于探讨所研究的生物标志物对[25(OH)D]状态的影响。
The correlation of metabolic and renal biomarkers with vitamin D status in postmenopausal women.
Background: To our knowledge, the mutual involvement of a variety of metabolic and renal biomarkers and vitamin D (determined as 25-hydroxyvitamin D [25(OH)D]) in postmenopausal women has not been examined yet. Therefore, we aimed to explore such a relationship by a thorough statistical multimarker approach.
Methods: A total of 150 (diabetes and cardiovascular disease-free) postmenopausal women were included. Anthropometric and biochemical parameters were measured. The fatty liver index (FLI) and Homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Univariate and multivariate binary logistic regression analyses were used to test the predictions of cardiometabolic markers for [25(OH)D] status. Principal component analysis (PCA) was applied to explore the effect of examined biomarkers on [25(OH)D] status.
期刊介绍:
The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
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