数字微流控生物芯片在线控制器的入侵检测

Sudeep Basu, S. Saha, Indrajit Pan
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引用次数: 4

摘要

微流控生物芯片高效、低成本的特点对临床诊断自动化具有启发意义。许多实验室导向的生化测试都变成了芯片操作。基于液滴的微流体是微流体科学的一个分支。实际上,这种流体装置能够同时操纵多个液滴。数字微流体生物芯片(DMFB)中液滴路径的主要目的是在微流体操作的不同流体和静态约束下,为每个液滴从指定的源电极到目标电极找到一条有效的路径。通过可编程智能控制器使整个操作更具可扩展性和可控性。为了满足当前需求和商业应用所需的灵活性,这种智能控制器必须考虑许多问题,如引脚优化,交叉参考最小化和路由过程中的污染检测。这使得智能控制器的任务非常复杂和具有挑战性。这些在线控制器需要以不同的时间间隔控制多个生物芯片板,以促进最佳的资源和时间利用率。然而,在线控制器非常容易受到广泛的网络攻击。在最近的文献中,各种各样的网络物理攻击被报道,这些攻击对物理系统的运行造成了显著的损害。该方法能够在物理系统级别判断此类恶意操作。这将有助于监控物理操作的行为,并可以在任何异常情况下停止操作。实验结果表明,该方法可以在最小的计算资源消耗下准确地检测出错误和多余的操作。误差检测效率的比较表明,该方法比现有方法有较大的提高。
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Intrusion Detection in Online Controller of Digital Microfluidic Biochips
Efficient and cost optimal feature of micro fluidic based biochips are inspiring in automation of clinical diagnostics. Many laboratory oriented biochemical tests are transfigured into on chip operations. Droplet based micro fluidic is a sub-category of micro fluidic sciences. Actually this type of fluidic device is capable of manipulating multiple droplets concurrently. The main aim of droplet routing in a Digital Micro fluidic Biochip (DMFB) is to find an efficient path for each droplet from a designated source electrode to a destination electrode under different fluidic and static constraints of micro fluidic operations. The whole operation can be make more scalable and controlled through a programmable intelligent controller. In order to match up with the current needs and required flexibility of commercial applications, this intelligent controller has to take care of many issues like pin optimization, cross reference minimization and contamination detection during routing. This makes the task of intelligent controller quite complex and challenging. These online controllers need to control multiple biochip boards at different time intervals to promote optimum resource and time utilization. However, online controllers are very susceptible to wide range of cyber attacks. In recent literature, varieties of cyber physical attacks have been reported which cause remarkable impairment on the operation of physical system. This proposed method is able to adjudge such malicious operations at the physical system level. This will help to monitor the behavior of the physical operation and can stall it under any abnormality in operation. Experimental findings show that the proposed technique can detect the errors and superfluous operations accurately with minimum consumption of computing resources. Comparative performance of error detection efficiency shows betterment over the existing methods.
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