布洛芬/β-CD机械混合物的控制退火络合

Q4 Chemistry Bulgarian Chemical Communications Pub Date : 2019-01-01 DOI:10.34049/bcc.51.3.4907

Stiliyana Pereva, Tsveta Sarafska, V. Petrov, M. Spassova, S. Bogdanova, T. Spassov

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引用次数: 0

摘要

采用改进的熔融法，将药物仅溶解在布洛芬与β-环糊精的机械混合物中，形成布洛芬/β-环糊精配合物。用差示扫描量热法测定了水分子从CD腔中释放后布洛芬在β-CD中的包合情况，并用x射线衍射和红外光谱分析证实了布洛芬包合的存在。关键词:β-环糊精，布洛芬，包合物，熔融法

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Ibuprofen/β-CD complexation by controlled annealing of their mechanical mixture

Ibuprofen/β-cyclodextrin complex was formed applying a modified melting method, consisting in melting only the drug in the mechanical mixture of ibuprofen and β-cyclodextrin. The ibuprofen inclusion into β-CD was monitored by differential scanning calorimetry after initial release of the water molecules from the CD cavity and was proved by X-ray diffraction and FTIR analyses. Keywords: β-cyclodextrin, ibuprofen, inclusion complex, melting method

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