循环mirna能预测治疗反应吗?

L. Kannappa
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摘要

结直肠癌(CRC)是第三大常见癌症,2012年全球有近140万新发病例。迫切需要一种新的无创血液检测来改善CRC的早期发现和监测。mirna是一种小的非编码rna,参与细胞增殖、存活和死亡等基本过程。研究已经在癌症患者的血浆中发现了稳定形式的mirna。本研究旨在评估循环microrna是否能预测治疗反应。
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Are Circulating miRNAs Predictive of Response to Therapy?
Colorectal cancer (CRC) is the third commonest cancer with nearly 1.4 million new cases identified throughout the world in 2012. There is a pressing need for a new non-invasive blood-based test to improve early detection and monitoring of CRC. MiRNAs are small non-coding RNAs involved in fundamental cell processes such as proliferation, survival and death. Studies have identified miRNAs in plasma of cancer patients in a stable form. This study aimed to evaluate whether circulating microRNAs are predictive of response to therapy. 
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