Facile Fabrication of Cell Delivery Microrobot Using Self-rolled-up Method

In this paper, we propose the simple and versatile approach for fabrication of the biocompatible polymer-based microrobot for active and precise cell delivery. The typical shape of the pattern was UV cured and the patterned sheet was then immersed in the ethanol solution to weaken the adhesion with the substrate. After few hours the patterned sheet rolled inward, spontaneously, as delaminating from the substrate. The rolled-up structure was then coated with amine functionalized magnetic nanoparticles so that it can be controlled under the external magnetic field. To evaluate the locomotion ability and biocompatibility of the microrobot, various tests were conducted using electromagnetic actuation (EMA) system and cell culture experiment.