苦参醇提物对Wistar大鼠的急性毒性评价

R. Pal, A. Mishra
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引用次数: 4

摘要

Dhatryadi ghrita由dhatri组成,自古以来就被认为具有许多治疗特性。它不会造成任何毒性或副作用,但没有科学证据。本研究的目的是根据经济合作与发展组织(OECD)制定的标准,研究刺荆草甲醇提取物对wistar大鼠(180-200g)的毒性作用,以确定其安全参数。以第1组为对照,比较各组大鼠给予不同浓度提取物后的行为。组2、组3、组2、组4分别以1000 mg/kg、2000 mg/kg、3000 mg/kg给药,组5按4000 mg/kg给药。实验的急性毒性研究处理的不同剂量从1000-4000 mg/kg不等,直到实验期间观察14天为止,没有造成任何动物死亡。Dhatryadi Ghrita对啮齿动物和老鼠是安全的。因此,提取物是更安全的治疗用途的药物制剂。急性毒性研究发现,不同浓度的Ghrita是完全安全无毒的。
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Evaluation of Acute Toxicity of the Methanolic Extract of Dhatryadi Ghrita in Wistar Rats
Dhatryadi ghrita consists of dhatri, is known to have number of curative properties since ages. It does not causes any toxic or adverse effect, but there is no scientific evidence available.The present piece of research is aimed to study the toxic effects in order to lay down the safety parameters of methanolic extract obtained from Dhatryadi Ghrita in wistar rats (180-200g) as per the standards set by The Organization for Economic Cooperation and Development or OECD.Group 1 was used as a control for comparing the behavior of rats from all groups which were administered extracts of different concentrations. The animals in Group 2 were administered a dose of 1000, Group 3, 2000, and Group 4, 3000, respectively in the units of mg/kg and Group 5 were given a dose of 4000 mg/kg accordingly.The acute toxicity studies of the experiment dealing with different doses as varying from 1000-4000 mg/kg, which did not resulted in any death of any animal till 14 days of observation in the experimentation period.Dhatryadi Ghrita is safe in rodent and mice. Hence, the extract is safer for therapeutic use in pharmaceutical formulations. Ghrita in different concentrations were found to be completely safe and non-toxic under acute toxicity studies.
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