预交联混合水凝胶用于3D生物打印过程:流变分析

IF 1 Q4 ENGINEERING, MANUFACTURING Journal of Micro and Nano-Manufacturing Pub Date : 2022-06-27 DOI:10.1115/msec2022-85700
Slesha Tuladhar, Cartwright Nelson, Md. Ahasan Habib
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引用次数: 0

摘要

在当今世界,用于再生医学的生物打印技术越来越受欢迎。尽管这是一个被严格研究的领域,但仍有一些挑战有待解决。几何保真度和机械复杂性是定制支架可打印性的障碍。探索组合物的流变特性有助于我们了解生物材料的物理和机械特性,这些特性与长丝的可打印性以及最终支架的几何保真度密切相关。为了保证支架的结构完整性,使用了羧甲基纤维素(CMC)等增粘剂和CaCl2、CaSO4等交联剂。这些交联剂可以在(交联前)和(交联后)挤出所考虑的组合物之前使用,以研究和比较结果。为此,制备了不同浓度的羧甲基纤维素(CMC,粘度增强剂)、海藻酸盐、CaCl2和CaSO4(交联剂)的混合物,保持最低固含量(≤8%)。每种组合物都进行了一系列流变学测试,如剪切变薄行为的流动曲线,恢复速率的三点触变,凝胶点的振幅测试和频率测试。这项研究彻底调查了组合物,当它们被引入交联剂和粘度增强剂时,这对3D打印世界至关重要。
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Pre-Crosslinked Hybrid Hydrogels for 3D Bio-Printing Process: Rheological Analysis
Bioprinting for regenerative medicine has been gaining a lot of popularity in today’s world. Despite being one of the rigorously studied fields, there are still several challenges yet to be solved. Geometric fidelity and mechanical complexities stand as roadblocks when it comes to the printability of the customized scaffolds. Exploring the rheological properties of the compositions helps us understand the physical and mechanical properties of the biomaterials which are closely tied to the printability of the filament and eventually, geometric fidelity of the scaffolds. To ensure the structural integrity of the scaffolds, viscosity enhancers such as Carboxymethyl Cellulose (CMC) and crosslinkers like CaCl2 and CaSO4 were used. These crosslinkers can be used before (pre-crosslinking) and after (post-crosslinking) the extrusion of considered compositions to investigate and compare the outcome. To do this, mixtures of Carboxymethyl Cellulose (CMC, viscosity enhancer), Alginate, and CaCl2 and CaSO4 (crosslinkers) were prepared at various concentrations maintaining minimum solid content (≤ 8%). Each composition was subjected to a set of rheological tests like Flow curve for shear thinning behavior, three-point thixotropic for recovery rate, amplitude test for gelation point, and frequency tests. This research thoroughly investigates compositions when they are introduced to crosslinkers and viscosity enhancers which can be crucial for 3D printing world.
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来源期刊
Journal of Micro and Nano-Manufacturing
Journal of Micro and Nano-Manufacturing ENGINEERING, MANUFACTURING-
CiteScore
2.70
自引率
0.00%
发文量
12
期刊介绍: The Journal of Micro and Nano-Manufacturing provides a forum for the rapid dissemination of original theoretical and applied research in the areas of micro- and nano-manufacturing that are related to process innovation, accuracy, and precision, throughput enhancement, material utilization, compact equipment development, environmental and life-cycle analysis, and predictive modeling of manufacturing processes with feature sizes less than one hundred micrometers. Papers addressing special needs in emerging areas, such as biomedical devices, drug manufacturing, water and energy, are also encouraged. Areas of interest including, but not limited to: Unit micro- and nano-manufacturing processes; Hybrid manufacturing processes combining bottom-up and top-down processes; Hybrid manufacturing processes utilizing various energy sources (optical, mechanical, electrical, solar, etc.) to achieve multi-scale features and resolution; High-throughput micro- and nano-manufacturing processes; Equipment development; Predictive modeling and simulation of materials and/or systems enabling point-of-need or scaled-up micro- and nano-manufacturing; Metrology at the micro- and nano-scales over large areas; Sensors and sensor integration; Design algorithms for multi-scale manufacturing; Life cycle analysis; Logistics and material handling related to micro- and nano-manufacturing.
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