羊草种子甲醇提取物对瑞士白化病小鼠的抗抑郁活性

Md Rashidur Rahman, Mohammad Ali, Mostakim Sharif, S. Sajon, M. Mannan, Md. Shahed-Al-Mahmud
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引用次数: 1

摘要

羊草传统上被用于治疗神经系统疾病,如抑郁症和焦虑症。迄今为止,已报道了其化学成分在不同疾病条件下的作用。传统的证据使我们确信草精(META)的甲醇提取物具有类似抗抑郁的活性。采用强迫游泳试验(FST)、悬尾试验(TST)和运动活动试验评估META的抗抑郁活性。以50、100、200 mg/kg体重剂量口服META种子部分,观察其对小鼠行为模型中枢神经系统兴奋剂活性的影响。在这里,我们报道了在给小鼠重复给药50、100和200 mg/kg后14天,META显著减少了FST中的静止时间。在所有剂量下,静止的强度都显著降低(p < 0.05),而在200 mg/kg时,我们发现效果最强。META具有抗抑郁样作用,分别以50、100和200 mg/kg口服14 d时,小鼠TST的不动性降低(p < 0.05)。此外,我们进行了运动活动测试,以检查运动刺激活动。META以50mg /kg、100mg /kg和200mg /kg的剂量连续使用14天,结果发现50mg /kg组的运动效果与对照组相似。有趣的是,100和200 mg/kg添加量显著提高了运动、饲养和排便(p < 0.05)。我们目前的研究结果表明,鼠叶草种子部分可能具有抗抑郁活性,可能用作神经系统疾病管理的支持治疗。
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Antidepressant-Like Activity of Methanolic Extract of the Seeds of Trachysperum ammi in Swiss Albino Mice
Trachysperum ammi has been traditionally used for the treatment of neurological disorders such as depression and anxiety. To date, T. ammi has reported for its chemical constituents in different diseases condition. The traditional evidence convinced us to perform the antidepressant-like activity of methanolic extract of Trachysperum ammi (META). The antidepressant activity of META assessed by using forced swimming test (FST), tail suspension test (TST), and locomotor activity test. The seed parts of META at doses level of 50, 100 and 200 mg/kg body weight administered orally to examine the CNS stimulants activity test in mice behavioral models. Here, we reported that META significantly reduced immobility time in the FST after repeated administration of 50, 100 and 200 mg/kg to mice for 14 days. The intensity of immobility significantly reduced at all of the doses (p < 0.05) whereas, we were found the strongest effect observed at 200 mg/kg. The antidepressant-like effect of META caused the reduction (p < 0.05) in the immobility in TST of mice when orally administered with 50, 100 and 200 mg/kg for 14 days, respectively. Additionally, we were executed locomotor activity test to check the motor stimulating activity. META has employed at a dosage of 50, 100 and 200 mg/kg for 14 days, the results have found that 50 mg/kg produced the locomotion effects as similar to the control group. Interestingly, the locomotion, rearing, and defecation significantly (p < 0.05) increased at the dosage of 100 and 200 mg/kg of META. Our present findings suggest that the seed parts of Trachysperum ammi may possess antidepressant-like activity which may use as a supportive treatment to management of neurological disorders.
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