生活方式和压力在糖尿病中的作用:一项病例对照研究

Q3 Pharmacology, Toxicology and Pharmaceutics Biomedical and Pharmacology Journal Pub Date : 2023-06-30 DOI:10.13005/bpj/2680
S. Harikrishnan, Radha Pulate, Steffy Terrance, Ousama Shikfa, J. Sreedharan
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引用次数: 0

摘要

背景:2型糖尿病(T2DM)是一种慢性代谢性疾病,其中胰岛素抵抗和胰岛素降低伴肝糖生成增加导致高血糖。这种情况无法治愈;然而,发病可以延迟,进展可以停止。本研究研究了生活方式和压力这两个可改变的危险因素与糖尿病的关系。该研究旨在评估压力和其他生活方式因素在糖尿病发生中的作用。阿联酋对糖尿病及其影响因素的研究还不多,因此本研究旨在确定阿联酋居民糖尿病与压力和生活方式之间的关系。方法:本病例-对照研究在阿拉伯联合酋长国阿治曼进行。参与者年龄在35岁到70岁之间。这项研究的持续时间为六个月。随机选择2型糖尿病患者和无糖尿病患者,采用问卷调查方式收集数据。在获得所需样本量的问卷后,使用SPSS-26进行数据分析。采用卡方检验发现分类变量之间存在相关性,以双侧p值< 0.05为显著性。样本量的计算采用显著性水平为5%,研究功率为80%。根据之前的研究,一般人群报告的压力为30%,而糖尿病患者的原始OR为2.4。这些基本信息用于计算本研究所需的最小样本量。病例-对照比为1:2。该研究的总参与者为195人(65例病例和130例对照)。纳入标准为所有国籍的男性和女性患者,排除标准为患有其他疾病的患者,如心血管疾病、癌症和孕妇。结果:共纳入205例受试者(71例;134控制)。研究结果显示,糖尿病患病率与婚姻状况、工作类型、总收入、运动量、身体质量指数(BMI)、工作性质无关(见表1和表2)。受试者年龄与糖尿病患病率差异有显著性P<0.001。心理应激也有显著相关性(P<0.05)。本研究也显示受试者的教育程度与糖尿病之间有显著的关联。这项研究显示了年龄和糖尿病、压力和糖尿病之间的联系。结论:本研究显示年龄和压力与糖尿病有显著关系。年龄是一个不可改变的危险因素,而压力是一个可改变的危险因素,因此降低压力水平有助于降低糖尿病的风险和进展。
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Role of Lifestyle and Stress on Diabetes Mellitus: A Case-Control Study
Background: Type 2-diabetes mellitus (T2DM) is a chronic metabolic disease in which insulin resistance and reduced insulin with increased hepatic glucose production lead to hyperglycemia. The condition cannot be cured; however, the incidence can be delayed and the progression can be halted. This study researches the association of 2 modifiable risk factors- lifestyle and stress with Diabetes Mellitus. The study aimed to assess the role of stress and other lifestyle factors on the occurrence of diabetes mellitus. Studies on diabetes mellitus and its factors have not been done much in United Arab Emirates (UAE) so this research is aimed to determine the association between diabetes mellitus and, stress and lifestyle among residents of UAE. Methods: This case-control study was conducted in Ajman, United Arab Emirates. The participants were in the age group of 35 to 70 years. The duration of this study was six months. Patients with type-2 diabetes mellitus and without diabetes mellitus were chosen randomly, and data were collected using a questionnaire. After obtaining the questionnaire with the desired sample size, data analysis was carried out using SPSS-26. The Chi-square test was used to find an association between the categorical variables and a two-sided P-value < 0.05 was taken as significant. The sample size was calculated by taking the level of significance as 5% and the power of the study as 80%. As per the previous study, the stress in the general population reported was 30% and the crude OR for DM those who are stressed as 2.4. This basic information is used to calculate the minimum required sample size for this study. The case-control ratio is taken as 1:2. The total participants for this study was 195 (65 cases and 130 controls). The inclusion criteria were both male and female patients of all nationalities and the exclusion criteria were patients with other disease conditions such as CVD, cancer and pregnant women. Results: A total of 205 participants were included in the study (71 cases; 134 controls). The study results showed that the prevalence of diabetes mellitus was not associated with marital status, type of job, total income, exercise, BMI (Body mass index), and the nature of work seen in Table 1 and Table 2. The age of the participants and the prevalence of diabetes mellitus showed a significance of P<0.001. The psychologic stress also showed a significant association (P<0.05). This study also showed a significant association between the educational qualification of the participant and Diabetes mellitus. This study showed an association between age and diabetes, as well as stress and diabetes. Conclusion: This study shows age and stress are significantly associated with diabetes. Age is a non-modifiable risk factor, while stress is a modifiable risk factor, so reducing stress levels can help reduce the risk and progression of diabetes mellitus.
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Biomedical and Pharmacology Journal
Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology
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1.20
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0.00%
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189
期刊介绍: Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.
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