FERALGINE™一种新型口服铁化合物

V. Talarico, L. Giancotti, Giuseppe Antonio Mazza, S. Marrazzo, R. Miniero, M. Bertini
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引用次数: 0

摘要

铁缺乏(ID)和缺铁性贫血(IDA)的管理主要集中在消除,如果可能的话,ID的根本原因;随后,其处理主要集中在铁储备的补充。硫酸亚铁(FS)仍然是主要的治疗方法,所有科学协会的指南都建议将其作为儿童和成人ID和IDA的一线治疗方法。然而,FS的有效性在很大程度上受到不良反应增加、依从性差和停止治疗的影响。FERALGINE™(FBC-A)是一种新型口服铁源。这种新分子是一种专利的双甘油酸亚铁螯合物(FBC)和海藻酸钠(AA)通过喷雾干燥技术得到的一比一的共加工化合物。在这篇简短的综述中提出的数据强调了FBC-A治疗的有效性和安全性,并支持将其用于成人IDA患者。此外,本综述还提供了初步证据,表明FBC-A可作为乳糜泻(CD)或炎症性肠病(IBD)患者ID/IDA的一线治疗药物。
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FERALGINE™ a New Oral iron Compound
Management of iron deficiency (ID) and iron deficiency anemia (IDA) is primarily focused to remove, when possible, the underlying cause of ID; subsequently its treatment is primary focused on iron stores repletion. Ferrous sulphate (FS) remains the mainstay of treatment and it is recommended as the first-line treatment of ID and IDA in children as in adults by all guidelines of scientific societies. However the effectiveness of FS is largely compromised by increased adverse effects, poor compliance and discontinuation of treatment. A new oral iron source named FERALGINE™ (FBC-A) has been recently developed. This new molecule is a patented co-processed one-to-one ratio compound between Ferrous Bysglicinate Chelate (FBC) and Sodium Alginate (AA), obtained by using a spray drying technology. The data presented in this short review highlight the efficacy and safety of the treatment with FBC-A and support its use in adult patients with IDA. Furthermore the present review also provides preliminary evidence to suggest FBC-A as first-line treatment for ID/IDA in patients with celiac disease (CD) or inflammatory bowel diseases (IBD).
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