Two Sisters were Diagnosed with Childhood Systemic Lupus Erythematous

We are herein reporting two female siblings with childhood-onset Systemic Lupus Erythematosus (SLE). The children were diagnosed as having SLE in reverse birth order at ages 2 and 6 years. Younger sister's initial symptoms were serositis, proteinuria, and hemolytic anemia with laboratory findings of hypocomplementemia and positive ANA/anti-dsDNA antibody. After 18 months, the older sister presented with high-grade fever, arthralgia proteinuria, oral mucous ulcer, butterfly rash, and positive ANA/anti-dsDNA antibody.