壳聚糖/氟化物纳米颗粒预防龋齿

Niousha Ebrahimi, A. Soleimani, J. Rashidiani, B. Malekafzali, H. Hosseinkhani, F. Abedini
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引用次数: 6

摘要

背景:龋齿仍然是一个主要的公共卫生问题。使用氟化物是预防蛀牙最有效的方法之一。目的:研究壳聚糖纳米颗粒包埋氟化物的体内效能。方法:采用三聚磷酸纳米粒子离子凝胶法制备氟化钠。利用zeta电位、颗粒大小、负载能力、封装效率和傅里叶变换红外光谱对纳米颗粒进行了表征。采用氟/壳聚糖与三聚磷酸盐交联的方法制备了壳聚糖/氟纳米颗粒。结果:制备的纳米颗粒尺寸为219 nm。zeta电位结果表明,在壳聚糖/三聚磷酸钠纳米颗粒中加入氟化钠降低壳聚糖的正电荷数,使zeta电位从+30.8 mV降低到+14.9 mV。最佳载药量为70%,包封率为30%。傅里叶变换红外光谱证实了三聚磷酸盐、壳聚糖和氟微粒之间的联系。体外表征表明纳米颗粒具有较高的氟吸收能力和平稳的释放特性。结论:本研究合成的氟/壳聚糖纳米颗粒可能是早期预防蛀牙的一种有前途的氟递送手段。
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Chitosan/Fluoride Nanoparticles for Preventing Dental Caries
Background: Dental caries is still a major public health problem. The use of fluoride is one of the most effective ways to prevent tooth decay. Objective: The purpose of this research was to investigate the effectiveness of fluoride entrapped in chitosan nanoparticles in vivo. Methods: Sodium fluoride was loaded in chitosan via ionic gelation of tripolyphosphate nanoparticles. Characterization of nanoparticles was investigated by using the zeta potential, size of particles, loading capacities, encapsulation efficiency, and Fourier Transforms Infrared Spectroscopy. Chitosan/ fluoride nanoparticles were fabricated by a method of fluoride/chitosan cross-linking with tripolyphosphate. Results: The size of nanoparticles was 219 nm. According to the zeta potential results, by adding sodium fluoride to chitosan/tripolyphosphate nanoparticles reducing the number of positive charges of chitosan, the result was diminished zeta potential from +30.8 mV to +14.9 mV. The optimum drug loading and percentage of entrapment efficiency were 70% and 30% respectively. Fourier transform infrared spectroscopy confirmed linked among tripolyphosphate, chitosan and fluoride nanoparticles. In vitro characterization of nanoparticles demonstrated higher fluoride uptake ability and smooth releasing profile. Conclusion: It is suggested that fluoride/chitosan nanoparticles synthesized in our study may be a promising means of delivering fluoride for the early prevention of tooth decay.
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