Pub Date : 2021-09-10DOI: 10.2174/2542579x03666210910164329
F. Chu, Xun Ding, T. Chow, L. Samaranayake
This prospective study aims to evaluate the one-year and two-year outcomes of root canals with apical periodontitis obturated in the presence or absence of cultivable micro-organisms, and define the influence on endodontic treatment outcome from different independent variables. 87 patients with 45 exposed and 43 unexposed canals who previously participated in a microbiological study of primary endodontic infections were invited back for review in 12 and 24 months after endodontic treatment. The review involves clinical examination, questionnaire interview and radiographic assessment in order to determine the treatment outcomes. The influence of independent variables, such as gender, age, tooth location, etc., on the treatment outcome, has also been analysed. A total of 85 teeth of 84 patients were reviewed one and two years after obturation. Chi-square test for trend showed that the one-year radiographic healing of apical lesions was significantly different between culture-positive and negative canals (P<0.05). However, there is no significant difference in the two-year radiographic healing between the two groups of canals (P>0.05). None of the independent variables was found to be significant in affecting the endodontic treatment outcome on logistic regression analysis. The presence of positive culture prior to obturation seemed to affect the healing of periapical tissues in a one-year review, but the effect appeared to be temporal and not affected the long-term outcome.
{"title":"Teeth with Apical Periodontitis Obturated in the Presence or Absence of Cultivable Micro-Organisms: a Two-Year Prospective Study of Treatment Outcomes","authors":"F. Chu, Xun Ding, T. Chow, L. Samaranayake","doi":"10.2174/2542579x03666210910164329","DOIUrl":"https://doi.org/10.2174/2542579x03666210910164329","url":null,"abstract":"\u0000\u0000This prospective study aims to evaluate the one-year and two-year outcomes of root canals with apical periodontitis obturated in the presence or absence of cultivable micro-organisms, and define the influence on endodontic treatment outcome from different independent variables.\u0000\u0000\u0000\u0000 87 patients with 45 exposed and 43 unexposed canals who previously participated in a microbiological study of primary endodontic infections were invited back for review in 12 and 24 months after endodontic treatment. The review involves clinical examination, questionnaire interview and radiographic assessment in order to determine the treatment outcomes. The influence of independent variables, such as gender, age, tooth location, etc., on the treatment outcome, has also been analysed.\u0000\u0000\u0000\u0000A total of 85 teeth of 84 patients were reviewed one and two years after obturation. Chi-square test for trend showed that the one-year radiographic healing of apical lesions was significantly different between culture-positive and negative canals (P<0.05). However, there is no significant difference in the two-year radiographic healing between the two groups of canals (P>0.05). None of the independent variables was found to be significant in affecting the endodontic treatment outcome on logistic regression analysis.\u0000\u0000\u0000\u0000The presence of positive culture prior to obturation seemed to affect the healing of periapical tissues in a one-year review, but the effect appeared to be temporal and not affected the long-term outcome.\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82012817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-05DOI: 10.2174/2542579x03666210805100624
S. Abaid, S. Zafar, E. Kruger, M. Tennant
Moyers probability tables have been widely used to determine the mesiodistal dimensions of unerupted canines and premolars for mixed dentition space analysis. Secular, racial, and sexual dimorphism have been reported in the literature and applicability of Moyer analysis has been doubted in many other populations. The present study was conducted to determine the applicability of Moyers probability tables and develop a more accurate prediction method in a contemporary Western Australian adolescent population if needed. A retrospective study including 500 participants [323 females, 177 males] between 13-18 years old attending the orthodontic private practice was conducted. Mesiodistal dimensions of selected participants were obtained from pre-orthodontic treatment digital dental records using Invisalign® technology [ Invisalign®, Align Tech¬nology, Santa Clara, CA, USA] Data were analysed using SPSS. New regression equations were derived based on the sum of permanent mandibular incisors, and probability tables were proposed for more accurate prediction. Significant differences were found between the measured sum of permanent canine-premolar segments and those predicted with the Moyers probability table, at all percentile levels, except the 50th percentile, where no significant difference was observed. Moyers probability table can be applied at the 50th percentile for estimation of sum of mesiodistal dimensions of canine-premolars segments. Newly developed regression equations and tables could be considered to provide more accurate mixed dentition space analysis.
莫耶斯概率表被广泛用于确定未出牙和前磨牙的中远端尺寸，用于混合牙列空间分析。世俗的、种族的和性别的二态性在文献中有报道，Moyer分析的适用性在许多其他人群中受到质疑。本研究旨在确定莫耶斯概率表的适用性，并在必要时开发一种更准确的预测方法，适用于当代西澳大利亚青少年人群。回顾性研究纳入500名13-18岁在正畸私人诊所就诊的患者[女性323人，男性177人]。使用Invisalign®技术(Invisalign®，Align technology, Santa Clara, CA, USA)从正畸治疗前的数字牙科记录中获得所选参与者的中远端尺寸。以下颌恒切牙总数为基础，建立了新的回归方程，并建立了概率表进行预测。除了第50个百分位数外，在所有百分位数水平上，永久性犬-前磨牙节的测量总数与Moyers概率表预测的总数之间没有显著差异。Moyers概率表可以在第50百分位数处用于估计犬-前磨牙节段中-远端尺寸之和。新开发的回归方程和回归表可以提供更准确的混合牙列空间分析。
{"title":"Determine the Applicability of Moyers Analysis in the Contemporary Western Australian Adolescent Population","authors":"S. Abaid, S. Zafar, E. Kruger, M. Tennant","doi":"10.2174/2542579x03666210805100624","DOIUrl":"https://doi.org/10.2174/2542579x03666210805100624","url":null,"abstract":"\u0000\u0000 Moyers probability tables have been widely used to determine the mesiodistal dimensions of unerupted canines and premolars for mixed dentition space analysis. Secular, racial, and sexual dimorphism have been reported in the literature and applicability of Moyer analysis has been doubted in many other populations.\u0000\u0000\u0000\u0000\u0000The present study was conducted to determine the applicability of Moyers probability tables and develop a more accurate prediction method in a contemporary Western Australian adolescent population if needed.\u0000\u0000\u0000\u0000\u0000 A retrospective study including 500 participants [323 females, 177 males] between 13-18 years old attending the orthodontic private practice was conducted. Mesiodistal dimensions of selected participants were obtained from pre-orthodontic treatment digital dental records using Invisalign® technology [ Invisalign®, Align Tech¬nology, Santa Clara, CA, USA] Data were analysed using SPSS. New regression equations were derived based on the sum of permanent mandibular incisors, and probability tables were proposed for more accurate prediction. \u0000\u0000\u0000\u0000\u0000Significant differences were found between the measured sum of permanent canine-premolar segments and those predicted with the Moyers probability table, at all percentile levels, except the 50th percentile, where no significant difference was observed.\u0000\u0000\u0000\u0000\u0000Moyers probability table can be applied at the 50th percentile for estimation of sum of mesiodistal dimensions of canine-premolars segments. Newly developed regression equations and tables could be considered to provide more accurate mixed dentition space analysis.\u0000\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78583570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-28DOI: 10.2174/2542579x03666210728141256
Andy Wai Kan Yeung
None of the webpages fulfilled the recommendations from the National Institute of Health and the American Medical Association of being written below a seventh-grade level. More online patient education materials for dental radiology were recommended, and they should be written in a more easily understood way.
{"title":"Readability of Online Patient Education Materials for Dental Radiology","authors":"Andy Wai Kan Yeung","doi":"10.2174/2542579x03666210728141256","DOIUrl":"https://doi.org/10.2174/2542579x03666210728141256","url":null,"abstract":"\u0000\u0000 None of the webpages fulfilled the recommendations from the National Institute of Health and the American Medical Association of being written below a seventh-grade level. More online patient education materials for dental radiology were recommended, and they should be written in a more easily understood way. \u0000\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90257066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-28DOI: 10.2174/2542579x03666210728130040
Andy Wai Kan Yeung, R. Tanaka, W. K. Leung
Growth and development in dental education globally depend on effective experience sharing and advocation of evidence-based practice, preferably tested via vigorous peer evaluation. This study aimed to evaluate the most cited dental education publications. The objectives were to identify the most productive entities, and the most frequently investigated themes and specialties. The top publications included 83 original articles, 15 reviews, 3 books, and 1 online document, written by 30 different authors, with 38 publications from dental journals not dedicated to education, and with an average of 5.5 citations per year. The most productive author was William Hendrickson. The most productive institutions were from Europe and the United States. There were 11 papers focused on operative dentistry, 9 on endodontology, 4 on special care dentistry, 2 on community dentistry, 2 on periodontology, and 2 on implantology. Within the top 102 list, 21 publications focused on the stress experienced by dental students at school. A multiple ANCOVA indicates that citation counts in these highly cited publications are associated with a number of authors and document types, such as “reviews/books/online document” compared with original articles (p < 0.001). Influential dental education studies were published on a variety of platforms. Over the past 20 years, the field witnessed the emergence of highly cited reports/articles. Similar to influential papers in various fields, the number of authors per top-cited dental education publications appeared to be associated with high citations indicating top quality and high appreciation/acceptance of the articles involved.
{"title":"The Top 102 Most Cited Publications Relevant to Dental Education","authors":"Andy Wai Kan Yeung, R. Tanaka, W. K. Leung","doi":"10.2174/2542579x03666210728130040","DOIUrl":"https://doi.org/10.2174/2542579x03666210728130040","url":null,"abstract":"\u0000\u0000 Growth and development in dental education globally depend on effective experience sharing and advocation of evidence-based practice, preferably tested via vigorous peer evaluation. \u0000\u0000\u0000\u0000\u0000 This study aimed to evaluate the most cited dental education publications. The objectives were to identify the most productive entities, and the most frequently investigated themes and specialties.\u0000\u0000\u0000\u0000\u0000The top publications included 83 original articles, 15 reviews, 3 books, and 1 online document, written by 30 different authors, with 38 publications from dental journals not dedicated to education, and with an average of 5.5 citations per year. The most productive author was William Hendrickson. The most productive institutions were from Europe and the United States. There were 11 papers focused on operative dentistry, 9 on endodontology, 4 on special care dentistry, 2 on community dentistry, 2 on periodontology, and 2 on implantology. Within the top 102 list, 21 publications focused on the stress experienced by dental students at school. A multiple ANCOVA indicates that citation counts in these highly cited publications are associated with a number of authors and document types, such as “reviews/books/online document” compared with original articles (p < 0.001). \u0000\u0000\u0000\u0000\u0000 Influential dental education studies were published on a variety of platforms. Over the past 20 years, the field witnessed the emergence of highly cited reports/articles. Similar to influential papers in various fields, the number of authors per top-cited dental education publications appeared to be associated with high citations indicating top quality and high appreciation/acceptance of the articles involved.\u0000\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78853454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-16DOI: 10.2174/2542579x03666210616150715
H. Lubis, A. Rachmawati, Stephani Tanius
Correction of skeletal Class II malocclusion generally requires extraction of the premolars, followed by the retraction of the anterior teeth to reduce overjet. Morphometric evaluation of alveolar bone can be used to study the limitation of tooth movement to avoid adverse effects. The purpose of this study is to measure the changes in the bone thickness of the maxillary incisors in skeletal Class II malocclusion patients after retraction and determine the relationship between changes in bone thickness and the amount of retractions using lateral cephalometric radiographs. The design of this study was to determine the cross-sectional changes in bone thickness in linear directions after retraction and the relationship between changes in bone thickness and the amount of retraction. Bone thickness in the linear directions was measured using digital cephalometric radiographs. The measurement results from tracing 43 lateral cephalometric before and after anterior retraction treatment showed that there was a difference in alveolar bone thickness at the 9mm level from the CEJ in a linear direction on the anterior retraction of skeletal Class II malocclusion maxillary incisors (p <0.05), however, there was no difference in alveolar bone thickness at levels 3 and 6 mm from CEJ in the linear direction, and the angular direction (p> 0.05). Changes in alveolar bone thickness did not correlate with the amount of incisor retraction (p> 0.05). The results showed that the change in labial alveolar bone thickness was not significantly correlated to the amount of retraction.
{"title":"Anterior Labial Alveolar Bone Thickness After Orthodontic Retraction Of Anterior Teeth","authors":"H. Lubis, A. Rachmawati, Stephani Tanius","doi":"10.2174/2542579x03666210616150715","DOIUrl":"https://doi.org/10.2174/2542579x03666210616150715","url":null,"abstract":"\u0000\u0000Correction of skeletal Class II malocclusion generally requires extraction of the premolars, followed by the retraction of the anterior teeth to reduce overjet. Morphometric evaluation of alveolar bone can be used to study the limitation of tooth movement to avoid adverse effects. The purpose of this study is to measure the changes in the bone thickness of the maxillary incisors in skeletal Class II malocclusion patients after retraction and determine the relationship between changes in bone thickness and the amount of retractions using lateral cephalometric radiographs.\u0000\u0000\u0000\u0000The design of this study was to determine the cross-sectional changes in bone thickness in linear directions after retraction and the relationship between changes in bone thickness and the amount of retraction. Bone thickness in the linear directions was measured using digital cephalometric radiographs.\u0000\u0000\u0000\u0000The measurement results from tracing 43 lateral cephalometric before and after anterior retraction treatment showed that there was a difference in alveolar bone thickness at the 9mm level from the CEJ in a linear direction on the anterior retraction of skeletal Class II malocclusion maxillary incisors (p <0.05), however, there was no difference in alveolar bone thickness at levels 3 and 6 mm from CEJ in the linear direction, and the angular direction (p> 0.05). Changes in alveolar bone thickness did not correlate with the amount of incisor retraction (p> 0.05).\u0000\u0000\u0000\u0000The results showed that the change in labial alveolar bone thickness was not significantly correlated to the amount of retraction.\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77505622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-01DOI: 10.2174/2542579x0301211103110525
F. Chu
{"title":"Preface: Digital Technologies in Current Dentistry","authors":"F. Chu","doi":"10.2174/2542579x0301211103110525","DOIUrl":"https://doi.org/10.2174/2542579x0301211103110525","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91074210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-09DOI: 10.2174/2542579x01666190924180448
A. C. Oliveira, S. Griza, R. R. de Moraes, A. Faria-E-Silva
To investigate the effect of filler content and the time spent before light-curing on mechanical properties of dual-cured cement. Experimental dual-cured resin cements were formulated with 60, 65 or 68wt% of filler. The viscosity of experimental cement was measured using a digital viscometer. Bar-shaped specimens (25 x 2 x 2 mm) were fabricated, while the light-curing was started immediately or 5 minutes after the insertion of cement into the mold (n = 7). A three-point bending test was performed and the values of flexural strength and elastic modulus were measured. The Vickers hardness of fractured specimens was measured on the surface of the cement. Data from viscosity were submitted to oneway ANOVA, while the data from mechanical properties were analyzed by two-way ANOVA. All pair-wise comparisons were performed using Tukey’s test (α = 0.05). The experimental cement with 68wt% of filler showed the highest viscosity and those with 60wt% showed the the lowest viscosity. Irrespective of the time spent before light-curing, the cement with 65wt% of filler presented the highest values of flexural strength and elastic modulus. The addition of 60wt% of filler resulted in the lowest elastic modulus, while 68wt% of filler resulted in lowest flexural strength. Regarding the hardness, the cement with 68wt% of filler showed the highest values, while there was no difference between 60 and 65wt% of filler. Filler content affected the mechanical properties of the experimental cement and this effect did not depend on the waiting time before the light-curing procedure.
探讨填料含量和光固化前时间对双固化水泥力学性能的影响。实验双固化树脂水泥分别以60%、65%或68%的填料配制。用数字式粘度计测量了实验水泥的粘度。制作棒状试样(25 x 2 x 2 mm)，同时在将水泥插入模具后立即或5分钟开始光固化(n = 7)。进行三点弯曲试验，并测量弯曲强度和弹性模量值。在水泥表面测量了断裂试样的维氏硬度。粘度数据采用单因素方差分析，力学性能数据采用双因素方差分析。采用Tukey检验进行全对比较(α = 0.05)。掺量为68wt%的试验水泥粘度最高，掺量为60wt%的试验水泥粘度最低。与光固化前的时间无关，掺量为65%的水泥具有最高的抗弯强度和弹性模量。掺量为60wt%的填料导致弹性模量最低，而掺量为68wt%的填料导致抗弯强度最低。在硬度方面，掺量为68wt%的水泥硬度最高，掺量为60 wt%和65wt%的水泥硬度无显著差异。填料含量对试验水泥的力学性能有影响，且这种影响与光固化前的等待时间无关。
{"title":"Effect of Filler Content and Waiting time Before Light-Curing on Mechanical Properties of Dual-Cured Cement","authors":"A. C. Oliveira, S. Griza, R. R. de Moraes, A. Faria-E-Silva","doi":"10.2174/2542579x01666190924180448","DOIUrl":"https://doi.org/10.2174/2542579x01666190924180448","url":null,"abstract":"\u0000\u0000To investigate the effect of filler content and the time spent before light-curing\u0000on mechanical properties of dual-cured cement.\u0000\u0000\u0000\u0000Experimental dual-cured resin cements were formulated with 60, 65 or 68wt% of filler.\u0000The viscosity of experimental cement was measured using a digital viscometer. Bar-shaped specimens\u0000(25 x 2 x 2 mm) were fabricated, while the light-curing was started immediately or 5 minutes\u0000after the insertion of cement into the mold (n = 7). A three-point bending test was performed and the\u0000values of flexural strength and elastic modulus were measured. The Vickers hardness of fractured\u0000specimens was measured on the surface of the cement. Data from viscosity were submitted to oneway\u0000ANOVA, while the data from mechanical properties were analyzed by two-way ANOVA. All\u0000pair-wise comparisons were performed using Tukey’s test (α = 0.05).\u0000\u0000\u0000\u0000The experimental cement with 68wt% of filler showed the highest viscosity and those with\u000060wt% showed the the lowest viscosity. Irrespective of the time spent before light-curing, the cement\u0000with 65wt% of filler presented the highest values of flexural strength and elastic modulus. The\u0000addition of 60wt% of filler resulted in the lowest elastic modulus, while 68wt% of filler resulted in\u0000lowest flexural strength. Regarding the hardness, the cement with 68wt% of filler showed the highest\u0000values, while there was no difference between 60 and 65wt% of filler.\u0000\u0000\u0000\u0000 Filler content affected the mechanical properties of the experimental cement and this\u0000effect did not depend on the waiting time before the light-curing procedure.\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84580580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-01DOI: 10.2174/2542579X01666190212150457
Niousha Ebrahimi, A. Soleimani, J. Rashidiani, B. Malekafzali, H. Hosseinkhani, F. Abedini
Background: Dental caries is still a major public health problem. The use of fluoride is one of the most effective ways to prevent tooth decay. Objective: The purpose of this research was to investigate the effectiveness of fluoride entrapped in chitosan nanoparticles in vivo. Methods: Sodium fluoride was loaded in chitosan via ionic gelation of tripolyphosphate nanoparticles. Characterization of nanoparticles was investigated by using the zeta potential, size of particles, loading capacities, encapsulation efficiency, and Fourier Transforms Infrared Spectroscopy. Chitosan/ fluoride nanoparticles were fabricated by a method of fluoride/chitosan cross-linking with tripolyphosphate. Results: The size of nanoparticles was 219 nm. According to the zeta potential results, by adding sodium fluoride to chitosan/tripolyphosphate nanoparticles reducing the number of positive charges of chitosan, the result was diminished zeta potential from +30.8 mV to +14.9 mV. The optimum drug loading and percentage of entrapment efficiency were 70% and 30% respectively. Fourier transform infrared spectroscopy confirmed linked among tripolyphosphate, chitosan and fluoride nanoparticles. In vitro characterization of nanoparticles demonstrated higher fluoride uptake ability and smooth releasing profile. Conclusion: It is suggested that fluoride/chitosan nanoparticles synthesized in our study may be a promising means of delivering fluoride for the early prevention of tooth decay.
{"title":"Chitosan/Fluoride Nanoparticles for Preventing Dental Caries","authors":"Niousha Ebrahimi, A. Soleimani, J. Rashidiani, B. Malekafzali, H. Hosseinkhani, F. Abedini","doi":"10.2174/2542579X01666190212150457","DOIUrl":"https://doi.org/10.2174/2542579X01666190212150457","url":null,"abstract":"\u0000\u0000Background: Dental caries is still a major public health problem. The use of fluoride is\u0000one of the most effective ways to prevent tooth decay.\u0000\u0000Objective: The purpose of this research was to investigate the effectiveness of fluoride entrapped in\u0000chitosan nanoparticles in vivo.\u0000\u0000Methods: Sodium fluoride was loaded in chitosan via ionic gelation of tripolyphosphate nanoparticles.\u0000Characterization of nanoparticles was investigated by using the zeta potential, size of particles,\u0000loading capacities, encapsulation efficiency, and Fourier Transforms Infrared Spectroscopy. Chitosan/\u0000fluoride nanoparticles were fabricated by a method of fluoride/chitosan cross-linking with\u0000tripolyphosphate.\u0000\u0000Results: The size of nanoparticles was 219 nm. According to the zeta potential results, by adding\u0000sodium fluoride to chitosan/tripolyphosphate nanoparticles reducing the number of positive charges\u0000of chitosan, the result was diminished zeta potential from +30.8 mV to +14.9 mV. The optimum\u0000drug loading and percentage of entrapment efficiency were 70% and 30% respectively. Fourier\u0000transform infrared spectroscopy confirmed linked among tripolyphosphate, chitosan and fluoride\u0000nanoparticles. In vitro characterization of nanoparticles demonstrated higher fluoride uptake ability\u0000and smooth releasing profile.\u0000\u0000Conclusion: It is suggested that fluoride/chitosan nanoparticles synthesized in our study may be a\u0000promising means of delivering fluoride for the early prevention of tooth decay.\u0000","PeriodicalId":10853,"journal":{"name":"Current opinion in dentistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76136403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：