[Glomerular disease].

Glomerular diseases are common causes of end-stage kidney disease in many parts of the world. The epidemiology of glomerular diseases varies across countries, contributed in part by genetic predisposition and in part by differences in screening and biopsy practices. While glomerulonephritis could be considered a primary condition due to inherent pathologies in the kidneys, e.g. minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy, it can be secondary to systemic conditions with distinct histopathological features on kidney biopsies. Likewise, even though histopathological patterns like mesangiocapillary and endocapillary glomerulonephritis may represent primary inflammatory features of kidney diseases, they may often manifest as a feature and be a suggestion of an underlying secondary systemic condition. For certain glomerular diseases, the natural history may be one of spontaneous remission, or may follow a remitting–relapsing course even with treatment. The approach to treatment involves general management measures to reduce proteinuria and provide symptomatic relief, with consideration for immunosuppression in those who present with significant morbidities or who have clinical features suggestive of a poor prognostic risk profile.