乳凝胶:促进药物局部吸收的研究进展

A. Shinde, A. Velhal, P. Jadhav, V. Redasani
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引用次数: 1

摘要

乳凝胶是一种正在发展的外用药物给药技术,如果对大多数外用有效药物的制剂进行更多的尝试,由于其双重释放控制系统(凝胶和乳液),将有利于皮肤护理和化妆品。皮肤作为诊断和治疗的靶器官的直接可用性是皮肤药理学的一个显著特征。透明凝胶作为化妆品和药品中一类重要的半固体制剂越来越受欢迎。尽管凝胶有许多好处,但一个主要的限制是水不溶性药物的输送,因为溶解度起着障碍作用,在药物释放过程中会出现问题。因此,一种基于乳化的策略被用来绕过这一屏障,甚至允许疏水的药物成分受益于凝胶的特殊功能。凝胶是由凝胶和乳剂混合而成的剂型。主要目标是产生一种凝胶状乳剂,以减少全身副作用,并以更少的药物剂量产生更显著的效果。触变性,无油,良好的涂抹性,易于拆卸,舒缓,可溶于水,保质期长,生物友好,半透明和吸引人的外观只是皮肤病学使用乳液的一些好处。因此,与目前现有的传统系统相比,凝胶可以作为一种良好的局部给药机制。
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A Review on Emulgel: Improvement of Topical Absorption of Drug
Emulgel is a developing topical drug delivery technique that, if more attempt is put for the preparations with majority of topically effective drugs, will be a benefit for dermal care and cosmetic products due to its dual release control system (gel and emulsion). The direct availability of the skin as a target organ for diagnosis and treatment is a distinguishing characteristic of dermatological pharmacology. Transparent gels have grown in popularity as a crucialclass of semisolid preparations in both cosmetics and pharmaceuticals. Despite the many benefits of gels, one major limitation is the delivery of water insoluble drugs because solubility acts as a barricade and a problem arises during drug release. As a result, an emulsion-based strategy is being employed to bypass this barrier, allowing even a hydrophobic medicinal component to benefit from the special features of gels. Emulgels are dosage forms made up of gels and emulsions that have been mixed. The major goal is to generate a jellified emulsion that will reduce systemic side effects and produce a more prominent effect with fewer drug doses. Thixotropic, greaseless, good Spreadability, easily removable, soothing, soluble in water, long shelf life, bio-friendly, translucent & appealing look are only a few of the benefits of emulgels for dermatological use. As a result, emulgels can be utilize as a good topical drug delivery mechanism than the currently existing traditional systems.
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