J. Godin-Ethier, J. Leiva, M. Toneva, I. Shaikh, A. Nelson
{"title":"吸入毒理学。","authors":"J. Godin-Ethier, J. Leiva, M. Toneva, I. Shaikh, A. Nelson","doi":"10.1201/9781420042627.sec5","DOIUrl":null,"url":null,"abstract":"• The continuous emergence of novel immunomodulatory therapeutics has brought more attention in the past decades to the evaluation of potential adverse effects on the immune system and in particular for the developing immune system in the early life stages. • A functional evaluation, such as the T-dependent antibody response is considered as most appropriate to address immunotoxicity in non-clinical setting1. • These assays need to be optimized for use in younger animals.","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":"270 1","pages":"1-250"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inhalation toxicology.\",\"authors\":\"J. Godin-Ethier, J. Leiva, M. Toneva, I. Shaikh, A. Nelson\",\"doi\":\"10.1201/9781420042627.sec5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"• The continuous emergence of novel immunomodulatory therapeutics has brought more attention in the past decades to the evaluation of potential adverse effects on the immune system and in particular for the developing immune system in the early life stages. • A functional evaluation, such as the T-dependent antibody response is considered as most appropriate to address immunotoxicity in non-clinical setting1. • These assays need to be optimized for use in younger animals.\",\"PeriodicalId\":17418,\"journal\":{\"name\":\"Journal of Toxicology and Environmental Health, Part A\",\"volume\":\"270 1\",\"pages\":\"1-250\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Toxicology and Environmental Health, Part A\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1201/9781420042627.sec5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology and Environmental Health, Part A","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1201/9781420042627.sec5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
• The continuous emergence of novel immunomodulatory therapeutics has brought more attention in the past decades to the evaluation of potential adverse effects on the immune system and in particular for the developing immune system in the early life stages. • A functional evaluation, such as the T-dependent antibody response is considered as most appropriate to address immunotoxicity in non-clinical setting1. • These assays need to be optimized for use in younger animals.
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