热力学和SARS-COV-2:对covid - 19后综合征的神经学影响

IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali Pub Date : 2021-07-26 DOI:10.1478/AAPP.992A3

U. Lucia, Giulia Grisolia, T. Deisboeck

{"title":"热力学和SARS-COV-2:对covid - 19后综合征的神经学影响","authors":"U. Lucia, Giulia Grisolia, T. Deisboeck","doi":"10.1478/AAPP.992A3","DOIUrl":null,"url":null,"abstract":"There is increasing evidence that infection with SARS-CoV-2 can cause a spectrum of neurological symptoms. In this paper, we develop a theoretical concept underlying such neurological COVID-19 consequences by employing a non-equilibrium thermodynamic approach that allows linking the neuronal electric potential with a virus-induced pH variation. Our theoretical findings support further experimental work on therapeutically correcting electrolyte imbalances, such as Na+ and K+, to attenuate the neurological effects of SARS-CoV-2. © 2021 by the author(s);licensee Accademia Peloritana dei Pericolanti (Messina, Italy). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).","PeriodicalId":43431,"journal":{"name":"Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"21","resultStr":"{\"title\":\"Thermodynamics and SARS-COV-2: Neurological effects in post-COVID 19 syndrome\",\"authors\":\"U. Lucia, Giulia Grisolia, T. Deisboeck\",\"doi\":\"10.1478/AAPP.992A3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There is increasing evidence that infection with SARS-CoV-2 can cause a spectrum of neurological symptoms. In this paper, we develop a theoretical concept underlying such neurological COVID-19 consequences by employing a non-equilibrium thermodynamic approach that allows linking the neuronal electric potential with a virus-induced pH variation. Our theoretical findings support further experimental work on therapeutically correcting electrolyte imbalances, such as Na+ and K+, to attenuate the neurological effects of SARS-CoV-2. © 2021 by the author(s);licensee Accademia Peloritana dei Pericolanti (Messina, Italy). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).\",\"PeriodicalId\":43431,\"journal\":{\"name\":\"Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2021-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1478/AAPP.992A3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1478/AAPP.992A3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 21

摘要

越来越多的证据表明，感染SARS-CoV-2可引起一系列神经系统症状。在本文中，我们通过采用非平衡热力学方法，将神经元电位与病毒诱导的pH变化联系起来，建立了一个理论概念，以解释这种神经学COVID-19后果。我们的理论发现支持进一步的实验工作，以治疗性地纠正电解质失衡，如Na+和K+，以减轻SARS-CoV-2的神经系统影响。©作者2021;被许可人Peloritana dei Pericolanti学院(意大利墨西拿)。本文是在知识共享署名4.0国际许可协议(https://creativecommons.org/licenses/by/4.0/)的条款和条件下发布的开放获取文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Thermodynamics and SARS-COV-2: Neurological effects in post-COVID 19 syndrome

There is increasing evidence that infection with SARS-CoV-2 can cause a spectrum of neurological symptoms. In this paper, we develop a theoretical concept underlying such neurological COVID-19 consequences by employing a non-equilibrium thermodynamic approach that allows linking the neuronal electric potential with a virus-induced pH variation. Our theoretical findings support further experimental work on therapeutically correcting electrolyte imbalances, such as Na+ and K+, to attenuate the neurological effects of SARS-CoV-2. © 2021 by the author(s);licensee Accademia Peloritana dei Pericolanti (Messina, Italy). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Atti Accademia Peloritana dei Pericolanti-Classe di Scienze Fisiche Matematiche e Naturali MULTIDISCIPLINARY SCIENCES-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

31 weeks

期刊介绍： This journal is of a multi- and inter-disciplinary nature and covers a broad range of fields including mathematics, computer science, physics, chemistry, biology, earth sciences, and their intersection. History of science is also included within the topics addressed by the journal. The transactions of the Pelorian Academy started out as periodic news sheets containing the notes presented by the members of the Divisions into which the Academy has been and still is organized, according to subject areas. The publication of these notes for the Division (“Classe”) of Mathematical, Physical and Natural Sciences is the responsibility of the Editorial Committee, which is composed of the Director of the division with the role of Chairman, the Vice-Director, the Secretary and two or more other members. Besides original research articles, the journal also accepts texts from conferences and invited talks held in the Academy. These contributions are published in a different section of the journal. In addition to the regular issues, single monographic supplements are occasionally published which assemble reports and communications presented at congresses, symposia, seminars, study meetings and other scientific events organized by the Academy or under its patronage. Since 2004 these transactions have been published online in the form of an open access electronic journal.