S-(5-芳基-1,3,4-恶二唑-2-基)o -烷基羰基酯和2-(5-芳基-1,3,4-恶二唑-2-基)硫代)乙酸酯的合成及其抗菌性能

A. Zi̇yaev, S. Sasmakov, T. Toshmurodov, M. Ziyaeva, J. Abdurakhmanov, S. Khasanov, Shakhnoza S. Azimova
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引用次数: 0

摘要

通过5-芳基-1,3,4-恶二唑-2-基与氯甲酸和氯乙酸的烷基酯相互作用,合成了S-(5-芳基-1,3,4-恶二唑-2-基)o -烷基碳硫酸酯(4-9)和2-(5-芳基-1,3,4-恶二唑-2-基)硫代乙酸酯(10-15)。用氯甲酸异丁酯合成的目标化合物(7 ~ 9)的收率为69 ~ 73%,用氯甲酸丙酯合成的收率为74 ~ 79%,用氯乙酸烷基酯合成的收率为86 ~ 92%。化合物的结构经IR、UV、1H和13C NMR确证。研究了这些化合物的抗菌和抗真菌活性。体外抑菌试验结果表明,S-(5-苯基(2-氯苯基)-1,3,4-恶二唑-2-基)o -丙基羰基(4-5)和S-(5-苯基(2-氯苯基)-1,3,4-恶二唑-2-基)o -异丁基羰基(7-8)对革兰氏阳性菌(枯草芽孢杆菌和金黄色葡萄球菌)具有较弱的选择性抑菌活性。同时,芳香环上有两个氯原子的化合物(13-15)和2-((5-芳基-1,3,4-恶二唑-2-基)硫代)乙酸烷基(10-15)没有表现出活性。
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Synthesis of S-(5-aryl-1,3,4-oxadiazol-2-yl) O-alkyl carbonothioate and alkyl 2-((5-aryl-1,3,4-oxadiazol-2-yl)thio) acetate, and their antimicrobial properties
The S-(5-aryl-1,3,4-oxadiazol-2-yl) O-alkyl carbonothioate (4-9) and the alkyl 2-((5-aryl-1,3,4-oxadiazol-2-yl)thio) acetate (10-15) were synthesized by interaction of 5-aryl-1,3,4-oxadiazole-2-thiones with alkyl esters of chloroformic acid and chloroacetic acid. The yields of target compounds (7-9) obtained with isobutyl chloroformate were 69-73%, compounds (4-6) with propyl chloroformate - 74-79% and compounds (10-15) with alkyl esters of chloroacetic acid - 86-92%, respectively. The structures of the synthesized compounds were confirmed by IR, UV, 1H and 13C NMR spectra. The antibacterial and antifungal activities of these compounds were investigated. The results of in vitro antimicrobial activity tests showed that S-(5-phenyl(2-chlorophenyl)-1,3,4-oxadiazol-2-yl) O-propyl carbonothioate (4-5) and S-(5-phenyl(2-chlorophenyl)-1,3,4-oxadiazol-2-yl) O-isobutyl carbonothioate (7-8) exhibited weak, but selective antibacterial activity against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus). At the same time, no activity was shown by compounds with two chlorine atoms in the aromatic ring (13-15) and alkyl 2-((5-aryl-1,3,4-oxadiazol-2-yl) thio) acetate (10-15).
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