卵泡旁突提取物对高脂饮食/链脲佐菌素诱导的糖尿病大鼠模型的潜在影响

Amel M. Soliman
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引用次数: 33

摘要

抗氧化疗法被认为对预防和治疗包括糖尿病在内的各种疾病有效。因此,本研究旨在探讨lividus parcentrotus extract (PLE)对高脂饮食(HFD)/链脲佐菌素(STZ)诱导糖尿病大鼠模型(T1DM和T2DM)后并发症的缓解作用。将36只雄性Wistar白化大鼠分为正常对照组、T1DM和T2DM治疗组和PLE治疗组。采用链脲佐菌素(60 mg/kg溶解于柠檬酸钠缓冲液中,0.1 mol/L, i.p)诱导T1DM。通过4周的高脂肪饮食(HFD)干预诱导T2DM,随后单次低剂量STZ (30 mg/kg溶解在0.1 mol/L柠檬酸缓冲液中,pH为4.5,i.p)。两种糖尿病大鼠模型血清均显著升高;空腹血糖、总蛋白、胆红素、精氨酸酶、转氨酶(AST和ALT)、碱性磷酸酶(ALP)、γ谷氨酰转移酶(GGT)活性、血脂参数和肝脏丙二醛(MDA)水平。然而,T1DM和T2DM大鼠血清胰岛素、肝脏葡萄糖6磷酸脱氢酶(G6PD)、谷胱甘肽还原(GSH)、一氧化氮(NO)和抗氧化酶水平下降。此外,本研究表明,通过改善糖尿病大鼠所研究参数的大部分改变,证实了PLE的降糖、降血脂和抗氧化能力。总之,PLE可能对两种类型的糖尿病的氧化应激和肝损伤有治疗作用,因此值得进一步研究。
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Potential impact of Paracentrotus lividus extract on diabetic rat models induced by high fat diet/streptozotocin

Antioxidant therapy has been thought to be effectual for the prevention and treatment of various diseases including diabetes. Therefore, the present study was designed to investigate the potency of Paracentrotus lividus extract (PLE) for alleviating the complications that resulted after induction of the diabetic rat models (T1DM and T2DM) using high fat diet (HFD)/streptozotocin (STZ). Thirty six male Wistar albino rats were assigned into normal control, T1DM and T2DM untreated, and PLE treated diabetic rat groups. Induction of T1DM was performed by streptozotocin injection (60 mg/kg of dissolved in sodium citrate buffer, 0.1 mol/L, i.p). T2DM induction through 4 weeks of high fat diet (HFD) intervention was followed by a single low dosage of STZ (30 mg/kg dissolved in 0.1 mol/L citrate buffer at pH 4.5, i.p). Both diabetic rat models showed a significant increase in serum; levels of fasting glucose, total protein, bilirubin, activities of arginase, transaminases (AST and ALT), alkaline phosphatase (ALP), γ glutamyl transferase (GGT), lipid profile parameters, and liver malondialdehyde (MDA). However, T1DM and T2DM rats have decreased levels of serum insulin, and liver glucose 6 phosphate dehydrogenase (G6PD), glutathione reduced (GSH), nitric oxide (NO), and antioxidant enzymes. Furthermore, the present study showed the hypoglycemic, hypolipidemic, and antioxidant potency of the PLE as confirmed by its ability for ameliorating most of the alterations caused in the studied parameters of diabetic rats. In conclusion, PLE may be useful as therapy against oxidative stress and liver damage in both types of diabetes mellitus and is therefore recommended for further studies.

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发文量
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审稿时长
47 weeks
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