The Transformation of Burnet's Immune Surveillance Cells into Natural Killer Cells and its Circumstances

by accidental misprint, instead of monocytoid noted as “macrophagic” in the legends. These new cells appeared clearly distinct from the already well known compact T cells (Figure 1), as a different new population (Figure 2), since their cytoplasm displayed fine round unstained white granulation. These larger rounded up lymphoid cells were cytotoxic to tumor cells; compare with hundreds of detailed complex pictures produced in the following years. This chapter also showed the tetraploid fused cells that have become later the first “hybridomata”, natural or artificially produced. The large granulated lymphoid cells we soon referred to as “Burnet’s Immune Surveillance Cells” and held them *Corresponding author: Joseph Geza Sinkovics, Retired Medical Director, the Cancer Institute, St. Joseph’s Hospital, Tampa FL, USA CaSe RepoRt